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首页> 外文期刊>Osaka City Medical Journal >3DSRT Evaluation of Responses of Alzheimer Type Dementia to Donepezil Hydrochloride Therapy
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3DSRT Evaluation of Responses of Alzheimer Type Dementia to Donepezil Hydrochloride Therapy

机译：3DSRT评价阿尔茨海默氏型痴呆对盐酸多奈哌齐治疗的反应

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Background Dementia of Alzheimer type (DAT) has been diagnosed objectively by using single photon emission tomography (SPECT). Donepezil hydrochloride (donepezil) is available for the symptomatic treatment of DAT. In a quantitative evaluation of therapeutic response in DAT, to compare with regional cerebral blood flows (rCBF) of various lesions before and after treatment, uptake in some sorts of cerebral regions of interests (ROIs) were used to be measured. But ROI analysis has problems such as poor reproducibility and lack of objectivity. The aim of this study was to investigate the evaluation of therapeutic response by three-dimensional stereotaxic ROI template (3DSRT), fully automated ROI analysis software, which can objectively estimate rCBF. Methods SPECT studies and Alzheimer's Disease Assessment Scale Japan cognitive Subscale function test ADAS-Jcog, as recognitive function test were performed for 22 patients (16 females, 6 males mean age=73.6 years) who were diagnosed as DAT. On 3DSRT, we compared ratios of the rCBF values of the parietal lobes, temporo-occipital lobes, hippocampus, corpus callosum and the frontal lobes/cerebellar hemispheres before and after medical treatment. To determine a cut-off number of areas exhibiting improved blood flow optimal as an indicator of improvement in cognitive function in response to treatment, receiver operating characteristics (ROC) analysis of number of areas improved blood flow was performed. Results The number of cases exhibiting changes in cognitive function was greatest when the cut-off number of areas exhibiting improved blood flow was set at 5. Conclusions The possibility of evaluation of therapeutic response to Donepezil in patients with DAT using 3DSRT was thus demonstrated by our study.
机译：背景技术阿尔茨海默氏型痴呆症（DAT）已通过单光子发射断层扫描（SPECT）进行了客观诊断。盐酸多奈哌齐（donepezil）可用于DAT的对症治疗。在DAT中治疗反应的定量评估中，为了与治疗前后各种病变的局部脑血流量（rCBF）进行比较，我们测量了某些感兴趣的大脑区域（ROIs）的摄取。但是，ROI分析存在重现性差和缺乏客观性等问题。这项研究的目的是研究通过三维立体定向ROI模板（3DSRT），全自动ROI分析软件对治疗反应的评估，该软件可以客观地估算rCBF。方法对22例诊断为DAT的患者（16例女性，6例男性，平均年龄= 73.6岁）进行SPECT研究和阿尔茨海默氏病评估量表日本认知子量表功能测试ADAS-Jcog，作为认知功能测试。在3DSRT上，我们比较了药物治疗前后顶叶，颞枕叶，海马，体和额叶/小脑半球的rCBF值的比率。为了确定表现出改善的血流的区域的截断数目，最佳地作为响应于治疗而认知功能改善的指标，进行了区域数目改善的血流的接收者操作特征（ROC）分析。结果当将改善血液流动的截断区域设置为5时，表现出认知功能改变的病例数最大。结论我们的研究证明了使用3DSRT评估DAT患者对多奈哌齐治疗反应的可能性。研究。

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