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首页> 外文期刊>Pediatric Cardiology >Transplacental Pharmacokinetics of Flecainide in the Gravid Baboon and Fetus
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Transplacental Pharmacokinetics of Flecainide in the Gravid Baboon and Fetus

机译：Flecainide在妊娠狒狒和胎儿中的经胎盘药代动力学

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摘要

The objective of this study was to characterize the transfer of flecainide across the placenta and determine the fetal: maternal ratio of flecainide in the gravid baboon. Flecainide acetate has been especially successful for the treatment of fetal supraventricular tachycardia associated with hydrops fetalis. However, the degree of transplacental transmission remains unknown. In this study, all animals were placed under general anesthesia. Flecainide 2.5 mg/kg was administered intravenously. Percutaneous umbilical blood sampling was performed simultaneously with maternal sampling. Flecainide levels were measured using high-performance liquid chromatography with ultraviolet detection. A total of six gravid baboons were studied at an average gestational age of 132 days. The mean maternal volume of distribution at steady state was 5.1 ± 1.8 L/kg. The mean combined elimination constant (k el) was 0.79 ± 0.19 hr−1 [95% confidence interval (CI), 0.64–0.93]. There was a linear relationship between maternal and fetal concentrations, with a ratio of fetal-to-maternal serum levels of 0.49 ± 0.05 (95% CI, 0.39–0.59). At steady state, fetal flecainide levels are ∼50% of maternal flecainide levels. Flecainide is rapidly distributed in the mother and fetus following a single intravenous dose with a maternal volume of distribution similar to that reported in normal healthy human adults. Since fetal levels correlate closely with maternal levels, we propose that it is possible to estimate fetal levels by monitoring maternal levels.
机译：这项研究的目的是表征氟卡尼特跨胎盘的转移，并确定妊娠狒狒中氟卡尼特的胎儿：母体比例。醋酸氟卡尼特已经特别成功地治疗了与胎儿水肿相关的胎儿室上性心动过速。然而，经胎盘传播的程度仍然未知。在这项研究中，将所有动物置于全身麻醉下。静脉注射氟卡尼特2.5 mg / kg。经皮脐带血采样与母体采样同时进行。使用具有紫外检测功能的高效液相色谱法测定氟卡尼的水平。总共研究了六个妊娠狒狒，平均胎龄为132天。孕妇在稳定状态下的平均分布体积为5.1±1.8 L / kg。平均合并消除常数（k el ）为0.79±0.19 hr-1 [95％置信区间（CI），0.64–0.93]。母体与胎儿浓度之间存在线性关系，胎与母血清水平之比为0.49±0.05（95％CI，0.39–0.59）。在稳定状态下，胎儿氟卡尼水平约为母体氟卡尼水平的50％。单次静脉注射后，氟卡尼特在母亲和胎儿中迅速分布，其母体分布与正常健康成人中报道的相似。由于胎儿水平与母亲水平密切相关，因此我们建议可以通过监测母亲水平来估计胎儿水平。

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  • 来源
    《Pediatric Cardiology》 |2005年第6期|815-820|共6页
  • 作者

    V.V. Dimasc; M.D. Taylor; C.B. Cunnyngham; E.D. Overholt; D.W.A. Bourne; J.R. Stanely III; A. Sheikh; R. Wolf; B. Valentine; K.E. Ward;

  • 作者单位

    Lillie Frank Abercrombie Section of Pediatric Cardiology Baylor College of Medicine Texas Children’s Hospital;

    Lillie Frank Abercrombie Section of Pediatric Cardiology Baylor College of Medicine Texas Children’s Hospital;

    Department of Pediatrics Section of Pediatric Cardiology University of Oklahoma Health Sciences Center Children’s Hospital of Oklahoma;

    Department of Pediatrics Section of Pediatric Cardiology University of Oklahoma Health Sciences Center Children’s Hospital of Oklahoma;

    Department of Pharmaceutics College of Pharmacy University of Oklahoma Health Sciences Center;

    Maternal–Fetal Medicine Department of Obstetrics and Gynecology University of Oklahoma Health Sciences Center;

    Maternal–Fetal Medicine Department of Obstetrics and Gynecology University of Oklahoma Health Sciences Center;

    Department of Animal Resources University of Oklahoma Health Sciences Center BMSB 1 203;

    Department of Animal Resources University of Oklahoma Health Sciences Center BMSB 1 203;

    Department of Pediatrics Section of Pediatric Cardiology University of Oklahoma Health Sciences Center Children’s Hospital of Oklahoma;

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  • 正文语种 eng
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  • 关键词

    Supraventricular tachycardia; Fetus; Flecainide; Transplacental pharma kinectics;

    机译：室上性心动过速;胎儿;氟卡尼特;经胎盘药理动力学;

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