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首页> 外文期刊>Pediatric Cardiology >Evaluation of Preclinical Atherosclerosis by Flow-Mediated Dilatation of the Brachial Artery and Carotid Artery Analysis in Patients with a History of Kawasaki Disease
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Evaluation of Preclinical Atherosclerosis by Flow-Mediated Dilatation of the Brachial Artery and Carotid Artery Analysis in Patients with a History of Kawasaki Disease

机译：川崎病史患者肱动脉血流介导性扩张和颈动脉分析评估临床前动脉粥样硬化

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Cardiac sequelae of Kawasaki disease are an important cause of ischemic heart disease in young adults. The possibility of early progression of atherosclerosis following Kawasaki disease is therefore of great concern. We examined whether preclinical atherosclerotic changes are seen in patients with a history of Kawasaki disease, and whether these changes appear in all or in only a proportion of patients. Sixty-five patients with a history of Kawasaki disease, aged 13.1 ± 2.1 years, and 20 aged-matched controls participated in the study. All subjects underwent flow-mediated dilatation (FMD) of the brachial artery and analysis of carotid artery size and pulse-wave transmission. Patients were classified into four groups depending on the severity of the maximum coronary artery lesion: group 0 (normal), group 1 (mild), group 2 (moderate), and group 3 (severe). There was no statistical difference in the carotid artery analyses between the four groups. FMD (mean ± SD) was significantly lower in groups 2 and 3 than in groups 0 and 1 and the control group (group 0, 19.4 ± 3.9%; group 1, 19.5 ±4.1%; group 2, 8.9 ± 2.8%; group 3, 4.2 ± 1.5%; control group, 18.8 ± 2.8%; p < 0.0001). There was a significantly negative correlation between the severity of the coronary artery lesion and FMD (p < 0.0001 for both). Endothelial dysfunction was revealed by FMD in patients with persistent coronary artery lesions subsequent to Kawasaki disease. Preclinical atherosclerosis may be present only in patients with coronary aneurysms.
机译：川崎病的心脏后遗症是年轻人缺血性心脏病的重要原因。因此，川崎病后动脉粥样硬化早期发展的可能性备受关注。我们检查了有川崎病史的患者是否出现临床前动脉粥样硬化改变，以及这些改变是否出现在全部或仅部分患者中。 65名具有川崎病病史的患者，年龄13.1±2.1岁，有20名年龄匹配的对照组参加了研究。所有受试者均进行肱动脉血流介导的扩张（FMD），并分析颈动脉大小和脉搏波传播。根据最大冠状动脉病变的严重程度将患者分为四组：第0组（正常），第1组（轻度），第2组（中度）和第3组（严重）。四组之间的颈动脉分析无统计学差异。第2组和第3组的FMD（平均值±SD）显着低于第0组和第1组以及对照组（第0组，19.4±3.9％;第1组，19.5±4.1％;第2组，8.9±2.8％; 3、4.2±1.5％；对照组，18.8±2.8％； p <0.0001）。冠状动脉病变的严重程度与FMD之间存在显着的负相关（两者均p <0.0001）。川崎病后患有持续性冠状动脉病变的患者在FMD中发现了内皮功能障碍。临床前动脉粥样硬化可能仅存在于冠状动脉瘤患者中。

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