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Predictors of Outcome of Myocarditis

机译：心肌炎结果的预测因子

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摘要

Heart failure from myocarditis may be transient or may progress to unremitting severe cardiac failure. This study was performed to determine the outcomes and prognostic features of pediatric patients with myocarditis. Patients with the diagnosis of myocarditis between 1990 and 2001 were identified through the coding system of Yale–New Haven Hospital. A total of 28 patients were included, with ages ranging from 1 day to 20 years. Before discharge, 11 patients developed unremitting severe cardiac failure. Of the remaining 17 patients, at the time of discharge 10 had normal systolic function and 7 had decreased systolic function. Unremitting cardiac failure developed in 9 of 14 patients (64%) with an ejection fraction <30% and in only 2 of 14 (14%) of those with an ejection fraction ≥30% on admission (p < 0.01). Furthermore, shortening fraction <15%, left ventricular dilatation, and moderate to severe mitral regurgitation on admission as well as arrhythmia were significantly associated with development of unremitting severe cardiac failure. In this series of patients with myocarditis, by the time of discharge 39% of the patients had developed unremitting severe cardiac failure, 25% had depressed systolic function, and 36% had normal systolic function. Predictive factors at admission for poor outcome were ejection fraction <30%, shortening fraction <15%, left ventricular dilatation, and moderate to severe mitral regurgitation.
机译：心肌炎引起的心力衰竭可能是短暂的，也可能发展为持续的严重心力衰竭。进行这项研究是为了确定小儿心肌炎患者的结局和预后特征。通过耶鲁大学-纽黑文医院的编码系统，鉴定出1990年至2001年间诊断为心肌炎的患者。总共包括28位患者，年龄从1天到20岁不等。在出院前，有11名患者出现了持续的严重心力衰竭。在其余的17例患者中，出院时10例收缩功能正常，而7例收缩功能降低。 14例射血分数<30％的患者中有9例（64％）出现了持续性心力衰竭，入院时射血分数≥30％的14例中只有2例（14％）（p <0.01）。此外，缩短分数<15％，左心室扩张，入院时中度至重度二尖瓣反流以及心律不齐与持续性严重心力衰竭的发展密切相关。在这一系列的心肌炎患者中，出院时有39％的患者出现了持续的严重心力衰竭，其中25％的收缩功能下降，而36％的收缩功能正常。入院时不良预后的预测因素为射血分数<30％，缩短分数<15％，左心室扩张以及中度至重度二尖瓣反流。

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  • 来源
    《Pediatric Cardiology》 |2004年第4期|379-384|共6页
  • 作者

    B. Kühn; E. D. Shapiro; T. A. Walls; A. H. Friedman;

  • 作者单位

    Department of Pediatrics Yale University School of MedicineCurrent address: Department of Cardiology Children’s Hospital Boston;

    Department of Epidemiology and Investigative Medicine and Children’s Clinical Research Center Yale University School of Medicine;

    Department of Pediatrics Yale University School of Medicine;

    Section of Pediatric Cardiology Yale University School of Medicine;

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  • 正文语种 eng
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  • 关键词

    Myocarditis; Cardiac failure;

    机译：心肌炎;心脏衰竭;

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