cRGD Grafted siRNA Nano-constructs for Chemosensitization of Gemcitabine Hydrochloride in Lung Cancer Treatment

Nirav Khatri; Mohan Rathi; Dipesh Baradia; Ambikanandan Misra

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cRGD Grafted siRNA Nano-constructs for Chemosensitization of Gemcitabine Hydrochloride in Lung Cancer Treatment

机译：cRGD嫁接的siRNA纳米构建体对盐酸吉西他滨的化学增敏作用在肺癌治疗中的作用

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Purpose The aim of present investigation was to effectively deliver ribonucleotide reductase subunit 1 (RRM1) targeted siRNA and assess chemo-sensitization of lung cancer cells against Gemcitabine hydrochloride. It was hypothesised that effective and selective delivery of RRM1 siRNA will help in the treatment of lung cancer chemotherapy using Gemcitabine hydrochloride by reducing drug dose and thereby, reduces dose related toxicity of Gemcitabine hydrochloride.

机译：目的本研究的目的是有效递送靶向核糖核苷酸还原酶亚基1（RRM1）的siRNA，并评估肺癌细胞对盐酸吉西他滨的化学敏感性。假设有效和选择性地递送RRM1 siRNA可以通过减少药物剂量来帮助使用盐酸吉西他滨治疗肺癌化疗，从而降低盐酸吉西他滨的剂量相关毒性。

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《Pharmaceutical Research》 |2015年第3期|806-818|共13页
作者
Nirav Khatri; Mohan Rathi; Dipesh Baradia; Ambikanandan Misra;
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Pharmacy Department The Maharaja Sayajirao University of Baroda">(1);

Pharmacy Department The Maharaja Sayajirao University of Baroda">(1);

Pharmacy Department The Maharaja Sayajirao University of Baroda">(1);

Pharmacy Department The Maharaja Sayajirao University of Baroda">(1);

Pharmacy Department Faculty of Technology and Engineering The Maharaja Sayajirao University of Baroda">(2);

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1. cRGD Grafted siRNA Nano-constructs for Chemosensitization of Gemcitabine Hydrochloride in Lung Cancer Treatment [J] . Khatri Nirav, Rathi Mohan, Baradia Dipesh, Pharmaceutical research . 2015,第3期

机译：cRGD嫁接的siRNA纳米构建体用于盐酸吉西他滨的化学增敏在肺癌治疗中的作用。
2. Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation [J] . Molecular pharmaceutics . 2013,第2期

机译：用N-7苄基鸟嘌呤单磷酸鸟嘌呤氨基磷酸氨基磺酸盐原核苷酸（4Ei-1）处理乳腺癌和肺癌细胞会导致对吉西他滨的化学增敏作用并诱导eIF4E蛋白酶体降解
3. Antitumor activity of combination treatment combining gemcitabine with topotecin against human lung cancer xenografted in nude mice [J] . Fujita F, Koike M, Fujita M 癌と化学療法 . 2002,第4期

机译：结合吉西他滨与胸膜蛋白对裸鼠卵泡癌的牙蛋白蛋白与人肺癌的抗肿瘤活性
4. Inhalatory Co-Delivery of Anticancer Drugs and Antisense Oligonucleotides/siRNA for Lung Cancer Treatment [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：抗癌药物和反义寡核苷酸/ siRNA用于肺癌治疗的吸入式共递送
5. Peptide-mediated delivery of bioactive siRNAs for the treatment of oral cancer [D] . Alexander, Angela 2015

机译：肽介导的生物活性siRNA的递送用于口腔癌的治疗
6. Treatment of Breast and Lung Cancer Cells with a N-7 Benzyl Guanosine Monophosphate Tryptamine Phosphoramidate Pronucleotide (4Ei-1) Results in Chemosensitization to Gemcitabine and Induced elF4E Proteasomal Degradation [O] . Shui Li, Yan Jia, Blake Jacobson, -1

机译：用N-7苄基鸟苷的乳腺癌和肺癌细胞治疗单磷酸氨磷酸氨磷酸氨基磷酸酯（4EI-1）导致吉西他滨的化学敏化并诱导ELF4E蛋白质降解
7. P2-161: Phase II trial of induction chemotherapy with carboplatin and gemcitabine followed by concomitant gemcitabine and thoracic radiation followed by chemotherapy with carboplatin and gemcitabine for the treatment of stage IIIA and IIIB non-small cell lung cancer [O] . Arrieta Oscar, Martinez Luis, Gallardo Dolores, 2007

机译：P2-161：卡铂和吉西他滨诱导化疗联合伴用吉西他滨和胸腔放疗，然后卡铂与吉西他滨联合化疗治疗IIIA和IIIB期非小细胞肺癌的II期试验
8. Innovative Strategy for Treatment of Lung Cancer: Inhalatory Codelivery of Anticancer Drugs and siRNA for Suppression of Cellular Resistance [R] . Taratula, O. 2011

机译：治疗肺癌的创新策略：抗癌药物的抑制剂和抑制细胞耐药的siRNa

cRGD Grafted siRNA Nano-constructs for Chemosensitization of Gemcitabine Hydrochloride in Lung Cancer Treatment

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