Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques

D. Teutonico; F. Musuamba; H. J. Maas; A. Facius; S. Yang; M. Danhof; O. Della Pasqua

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Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques

机译：通过多变量和离散重采样技术生成虚拟患者

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Purpose Clinical Trial Simulations (CTS) are a valuable tool for decision-making during drug development. However, to obtain realistic simulation scenarios, the patients included in the CTS must be representative of the target population. This is particularly important when covariate effects exist that may affect the outcome of a trial. The objective of our investigation was to evaluate and compare CTS results using re-sampling from a population pool and multivariate distributions to simulate patient covariates.

机译：目的临床试验模拟（CTS）是药物开发过程中决策的宝贵工具。但是，为了获得逼真的模拟场景，CTS中包含的患者必须代表目标人群。当存在可能影响试验结果的协变量效应时，这一点尤其重要。我们研究的目的是使用人口池中的重新抽样和多元分布来模拟和评估患者的协变量，以评估和比较CTS结果。

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《Pharmaceutical Research》 |2015年第10期|3228-3237|共10页
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D. Teutonico; F. Musuamba; H. J. Maas; A. Facius; S. Yang; M. Danhof; O. Della Pasqua;
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1. Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques [J] . Teutonico D., Musuamba F., Maas H. J., Pharmaceutical research . 2015,第10期

机译：通过多变量和离散重采样技术生成虚拟患者
2. Bootstrap re-sampling technique to evaluate the optimal formulation of theophylline tablets predicted by non-linear response surface method incorporating multivariate spline interpolation. [J] . Arai H, Suzuki T, Kaseda C, Chemical and Pharmaceutical Bulletin . 2007,第4期

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3. Inverse Discrete Fourier Transform-Discrete Fourier Transform Techniques for Generating and Receiving Spectrally Efficient Frequency Division Multiplexing Signals | Science Publications [J] . Sahmed Idarwazeh American journal of engineering and applied sciences . 2012,第4期

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5. Generating potentials: The use of collage techniques in an adaptive reuse of the R.L. Hearn Generating Station, Toronto. [D] . MacIvor, William. 2009

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6. Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques [O] . D. Teutonico, F. Musuamba, H. J. Maas, -1

机译：通过多变量和离散重采样技术生成虚拟患者
7. Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques [O] . D. Teutonico, F. Musuamba, H. J. Maas, 2015

机译：通过多变量和离散重采样技术生成虚拟患者

Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques

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