Microneedle-Based Intradermal Delivery Enables Rapid Lymphatic Uptake and Distribution of Protein Drugs

Alfred J. Harvey; Scott A. Kaestner; Diane E. Sutter; Noel G. Harvey; John A. Mikszta; Ronald J. Pettis

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Microneedle-Based Intradermal Delivery Enables Rapid Lymphatic Uptake and Distribution of Protein Drugs

机译：基于微针的皮内递送可实现蛋白质药物的快速淋巴吸收和分布

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Purpose The purpose of this research was to examine the pharmacokinetics (PK) of drug uptake for microneedle-based intradermal (ID) delivery of several classes of protein drugs compared to standard subcutaneous (SC) administration.

机译：目的这项研究的目的是检查与标准皮下（SC）给药相比，几类蛋白质药物基于微针的皮内（ID）递送的药物吸收的药代动力学（PK）。

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《Pharmaceutical Research》 |2011年第1期|p.107-116|共10页
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Alfred J. Harvey; Scott A. Kaestner; Diane E. Sutter; Noel G. Harvey; John A. Mikszta; Ronald J. Pettis;
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1. Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs. [J] . Harvey AJ, Kaestner SA, Sutter DE, Pharmaceutical research . 2011,第1期

机译：基于微针的皮内递送可实现蛋白质药物的快速淋巴吸收和分布。
2. In vivo evaluation of a microneedle-based miniature syringe for intradermal drug delivery [J] . Urs O. Haefeli, Amir Mokhtari, Dorian Liepmann, Biomedical Microdevices . 2009,第5期

机译：基于微针的微型注射器用于皮内药物输送的体内评估
3. Solid lipid nanoparticle-based dissolving microneedles: A promising intradermal lymph targeting drug delivery system with potential for enhanced treatment of lymphatic filariasis [J] . Permana Andi Dian, Tekko Ismaiel A., McCrudden Maeliosa T. C., Journal of Controlled Release: Official Journal of the Controlled Release Society . 2019,第期

机译：基于固体脂质纳米粒子的溶解微针：具有有前途的皮内淋巴靶向药物递送系统，具有增强治疗淋巴丝体的潜力
4. Microneedle-based intradermal delivery is beneficial for lymphatic targetingdiagnostic and therapeutic applications [C] . Alfred J. Harvey, Scott A. Kaestner, Kristina Karl, Annual meeting exposition of the Controlled Release Society . 2009

机译：基于微针的皮内递送有利于淋巴靶向诊断和治疗应用
5. Mechanisms of intestinal microsphere uptake and quantitative analysis of organ distribution for applications of oral drug delivery [D] . Reineke, Joshua James 2008

机译：口服药物递送中肠道微球摄取的机制和器官分布的定量分析
6. Microneedle-Based Intradermal Delivery of the Anthrax Recombinant Protective Antigen Vaccine [O] . John A. Mikszta, John P. Dekker III, Noel G. Harvey, 2006

机译：基于微针的炭疽重组保护性抗原疫苗的皮内递送
7. Protein–Polymer Conjugates Synthesized Using Water-Soluble Azlactone-Functionalized Polymers Enable Receptor-Specific Cellular Uptake toward Targeted Drug Delivery [O] . Julia S. Kim, Allison R. Sirois, Analia J. Vazquez Cegla, 2019

机译：使用水溶性氮杂物官能化聚合物合成的蛋白质 - 聚合物缀合物使受体特异性细胞摄取能够朝向靶向药物递送

Microneedle-Based Intradermal Delivery Enables Rapid Lymphatic Uptake and Distribution of Protein Drugs

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