Vehicle Composition Influence on the Microneedle-Enhanced Transdermal Flux of Naltrexone Hydrochloride

Mikolaj Milewski; Audra L. Stinchcomb

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Vehicle Composition Influence on the Microneedle-Enhanced Transdermal Flux of Naltrexone Hydrochloride

机译：载体组成对盐酸纳曲酮微针增强透皮通量的影响

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Purpose Transdermal delivery of drugs is often limited by formidable barrier properties of stratum corneum (SC). Microneedles (MN) enable creation of transient microchannels in the SC and bypass this barrier. Many reports have focused on the great effectiveness of MN in improving percutaneous flux values of a variety of drugs over a large molecular size spectrum. The objective of the present study is to evaluate the influence of formulation on MN-enhanced transdermal transport of naltrexone hydrochloride (NTX HCl).

机译：目的药物的透皮递送通常受到角质层（SC）强大的屏障性能的限制。微针（MN）可以在SC中创建瞬态微通道并绕过此屏障。许多报告都集中在MN在改善大分子光谱范围内各种药物的经皮通量值方面的巨大功效。本研究的目的是评估制剂对MN增强的纳曲酮盐酸盐（NTX HCl）透皮运输的影响。

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《Pharmaceutical Research》 |2011年第1期|p.124-134|共11页
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Mikolaj Milewski; Audra L. Stinchcomb;
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1. Vehicle composition influence on the microneedle-enhanced transdermal flux of naltrexone hydrochloride. [J] . Milewski M, Stinchcomb AL Pharmaceutical research . 2011,第1期

机译：媒介物组成对盐酸纳曲酮微针增强透皮通量的影响。
2. Effect of formulation pH on transport of naltrexone species and pore closure in microneedle-enhanced transdermal drug delivery [J] . GhoshP., BrogdenN.K., StinchcombA.L. Molecular pharmaceutics . 2013,第6期

机译：制剂pH值对微针增强透皮给药中纳曲酮种类运输和孔封闭的影响
3. Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery. [J] . Yerramreddy TR, Milewski M, Penthala NR, Bioorganic and Medicinal Chemistry Letters . 2010,第11期

机译：新型3-O-聚乙二醇化羧酸甲酸酯和3-聚乙二醇化氨基甲酸酯前药，用于微针增强的透皮递送。
4. Effect of selected ionic and non-ionic membrane additives on the entrapment efficiency of naltrexone hydrochloride in niosomes [C] . Hamdv Abdelkader, Amal Kamal, Sayed Ismail, Annual meeting exposition of the Controlled Release Society . 2011

机译：选定的离子和非离子膜添加剂对盐酸纳曲酮在脂质体中的包封率的影响
5. Transdermal delivery of naltrexone by minimally invasive microneedle array application: Permeation enhancement of a water soluble compound across a lipophilic barrier. [D] . Banks, Stan Lee. 2008

机译：通过微创微针阵列应用透纳递送纳曲酮：增强水溶性化合物穿过亲脂性屏障的渗透性。
6. Effect of formulation pH on transport of naltrexone species and pore closure in microneedle-enhanced transdermal drug delivery [O] . Priyanka Ghosh, Nicole K. Brogden, Audra L. Stinchcomb -1

机译：pH值对微针增强透皮给药中纳曲酮物质运输和孔封闭的影响
7. Effect of Formulation pH on Transport of Naltrexone Species and Pore Closure in Microneedle-Enhanced Transdermal Drug Delivery [O] . Priyanka Ghosh, Nicole K. Brogden, Audra L. Stinchcomb 2013

机译：配方pH对微针增强透皮药物递送中纳曲酮物种及孔隙闭合输送的影响

Vehicle Composition Influence on the Microneedle-Enhanced Transdermal Flux of Naltrexone Hydrochloride

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