Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold

Devin M. Nelson; Priya R. Baraniak; Zuwei Ma; Jianjun Guan; N. Scott Mason; William R. Wagner

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Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold

机译：从可生物降解的聚氨酯支架中控制释放IGF-1和HGF

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Purpose Biodegradable elastomers, which can possess favorable mechanical properties and degradation rates for soft tissue engineering applications, are more recently being explored as depots for biomolecule delivery. The objective of this study was to synthesize and process biodegradable, elastomeric poly(ester urethane)urea (PEUU) scaffolds and to characterize their ability to incorporate and release bioactive insulin-like growth factor–1 (IGF-1) and hepatocyte growth factor (HGF).

机译：目的可生物降解的弹性体具有良好的机械性能和降解速率，适用于软组织工程应用，最近已被研究用作生物分子递送的储库。这项研究的目的是合成和加工可生物降解的弹性体聚（酯氨基甲酸酯）脲（PEUU）支架，并表征其结合和释放生物活性胰岛素样生长因子-1（IGF-1）和肝细胞生长因子的能力（ HGF）。

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《Pharmaceutical Research》 |2011年第6期|p.1282-1293|共12页
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Devin M. Nelson; Priya R. Baraniak; Zuwei Ma; Jianjun Guan; N. Scott Mason; William R. Wagner;
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1. Controlled release of IGF-1 and HGF from a biodegradable polyurethane scaffold. [J] . Nelson DM, Baraniak PR, Ma Z, Pharmaceutical research . 2011,第6期

机译：从可生物降解的聚氨酯支架中受控释放IGF-1和HGF。
2. The effects of rhBMP-2 released from biodegradable polyurethane/microsphere composite scaffolds on new bone formation in rat femora. [J] . Li B, Yoshii T, Hafeman AE Biomaterials . 2009,第35期

机译：从可生物降解的聚氨酯/微球复合支架释放的rhBMP-2对大鼠股骨新骨形成的影响。
3. Controlled release of dexamethasone acetate from biodegradable and biocompatible polyurethane and polyurethane nanocomposite. [J] . Da Silva GR, Ayres E, Orefice RL Journal of drug targeting . 2009,第5期

机译：从可生物降解和生物相容的聚氨酯和聚氨酯纳米复合材料中控制释放地塞米松乙酸酯。
4. Synthesis and characterization of biodegradable polyurethanes for controlled drug release [C] . Rong Zhang, Xuepeng Feng, Guirong Wang, World biomaterials congress . 2016

机译：用于药物控制释放的可生物降解聚氨酯的合成与表征
5. Toxicity of Potassium Permanganate and Potassium Peroxymonosulfate Controlled Released Biodegradable Polymer to the Non-target Organism Daphnia Magna. [D] . King, Niya Sade'. 2014

机译：高锰酸钾和过硫酸氢钾控制释放的可生物降解聚合物对非目标生物水蚤的毒性。
6. Controlled release of IGF-1 and HGF from a biodegradable polyurethane scaffold [O] . Devin M. Nelson, Priya R. Baraniak, Zuwei Ma, -1

机译：来自可生物降解的聚氨酯支架的IGF-1和HGF的控制释放
7. Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold [O] . Devin M. Nelson, Priya R. Baraniak, Zuwei Ma, 2011

机译：来自可生物降解的聚氨酯支架的IGF-1和HGF的控制释放
8. Effects of rhBMP-2 Released from Biodegradable Polyurethane/Microsphere Composite Scaffolds on New Bone Formation in Rat Femora. [R] . Li, B., Yoshii, T., Hafeman, A. E., 2009

机译：生物可降解聚氨酯/微球复合支架释放rhBmp-2对大鼠股骨新骨形成的影响。

Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold

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