Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters

Patrick J. Marsac; Tonglei Li; Lynne S. Taylor

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Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters

机译：使用实验确定的相互作用参数估算药物-聚合物在非晶态固体分散体中的混溶性和溶解度

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Purpose The amorphous form of a drug may provide enhanced solubility, dissolution rate, and bioavailability but will also potentially crystallize over time. Miscible polymeric additives provide a means to increase physical stability. Understanding the miscibility of drug–polymer systems is of interest to optimize the formulation of such systems. The purpose of this work was to develop experimental models which allow for more quantitative estimates of the thermodynamics of mixing amorphous drugs with glassy polymers.

机译：目的药物的无定形形式可以提供增强的溶解度，溶解速度和生物利用度，但随着时间的流逝也可能会结晶。混溶的聚合物添加剂提供了增加物理稳定性的手段。了解药物-聚合物系统的可混溶性对于优化此类系统的配方非常重要。这项工作的目的是开发实验模型，以便更定量地评估无定形药物与玻璃状聚合物混合的热力学。

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《Pharmaceutical Research》 |2009年第1期|p.139-151|共13页
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Patrick J. Marsac; Tonglei Li; Lynne S. Taylor;
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1. Estimation of drug-polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters. [J] . Marsac PJ, Li T, Taylor LS Pharmaceutical research . 2009,第10期

机译：使用实验确定的相互作用参数估算药物-聚合物在无定形固体分散体中的混溶性和溶解性。
2. Estimation of drug-polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters. [J] . Marsac PJ, Li T, Taylor LS Pharmaceutical research . 2009,第1期

机译：使用实验确定的相互作用参数估算药物-聚合物在无定形固体分散体中的混溶性和溶解性。
3. Drug-polymer miscibility, interactions, and precipitation inhibition studies for the development of amorphous solid dispersions for the poorly soluble anticancer drug flutamide [J] . Drug development and industrial pharmacy . 2019,第7a12期

机译：药物 - 聚合物混溶性，相互作用和沉淀抑制研究，用于开发无定形固体分散体，可溶性抗癌药物氟胺
4. Dissolution Enhancement of the Poorly Water Soluble Drug by Solid Dispersion with a Novel Polymeric Solubilizer (Soluplus ) [C] . Han-Pin Lira, Yidan Lan, David Bigio, Annual meeting exposition of the Controlled Release Society . 2010

机译：新型聚合物增溶剂（Soluplus）通过固体分散增强难溶性药物的溶解度
5. Investigating Crystallization tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions. [D] . Meng, Fan. 2015

机译：研究用于形成无定形固体分散体的药物-聚合物体系的结晶趋势，互溶性和分子相互作用。
6. A Novel Rheological Method to Assess Drug-Polymer Interactions Regarding Miscibility and Crystallization of Drug in Amorphous Solid Dispersions for Oral Drug Delivery [O] . Georgia Tsakiridou, Christos Reppas, Martin Kuentz, 2019

机译：评估与药物混溶和结晶的无定形固体分散体中口服药物递送的药物-聚合物相互作用的新型流变方法
7. Analytical and Computational Methods for the Estimation of Drug-Polymer Solubility and Miscibility in Solid Dispersions Development [O] . Djordje Medarević, Jelena Djuriš, Panagiotis Barmpalexis, 2019

机译：用于估计药物 - 聚合物溶解度和固体分散体发育中混溶性的分析和计算方法

Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters

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