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首页> 外文期刊>Pharmaceutical Research >Induction of Heme Oxygenase-1 (HO-1) and NAD[P]H: Quinone Oxidoreductase 1 (NQO1) by a Phenolic Antioxidant, Butylated Hydroxyanisole (BHA) and Its Metabolite, tert-Butylhydroquinone (tBHQ) in Primary-Cultured Human and Rat Hepatocytes
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Induction of Heme Oxygenase-1 (HO-1) and NAD[P]H: Quinone Oxidoreductase 1 (NQO1) by a Phenolic Antioxidant, Butylated Hydroxyanisole (BHA) and Its Metabolite, tert-Butylhydroquinone (tBHQ) in Primary-Cultured Human and Rat Hepatocytes

机译:酚醛抗氧化剂丁基羟基苯甲醚(BHA)及其代谢产物叔丁基对苯二酚(tBHQ)诱导血红素加氧酶-1(HO-1)和NAD [P] H:醌氧化还原酶1(NQO1)。大鼠肝细胞

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摘要

This study was aimed to investigate the effects of a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) on the induction of HO-1, NQO1 and Nrf2 proteins and their regulatory mechanisms in primary-cultured hepatocytes.
机译:这项研究旨在研究酚类抗氧化剂丁基羟基茴香醚(BHA)及其代谢物叔丁基对苯二酚(tBHQ)对HO-1,NQO1和Nrf2蛋白的诱导及其在原代培养肝细胞中的调控机制。

著录项

  • 来源
    《Pharmaceutical Research》 |2006年第11期|2586-2594|共9页
  • 作者单位

    Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey 160 Frelinghuysen Road Piscataway New Jersey 08854 USA;

    Department of Metabolism and Pharmacokinetics Bristol Myers Squibb Pharmaceuticals Princeton New Jersey USA;

    Department of Pharmacy National University of Singapore 18 Science Drive 4 Singapore s117543 Singapore;

    Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey 160 Frelinghuysen Road Piscataway New Jersey 08854 USA;

    Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey 160 Frelinghuysen Road Piscataway New Jersey 08854 USA;

    Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey 160 Frelinghuysen Road Piscataway New Jersey 08854 USA;

    Department of Medicine UMDNJ-Robert Wood Johnson Medical School 675 Hoes Lane Piscataway New Jersey USA;

    Department of Metabolism and Pharmacokinetics Bristol Myers Squibb Pharmaceuticals Princeton New Jersey USA;

    Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey 160 Frelinghuysen Road Piscataway New Jersey 08854 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    butylated hydroxyanisole (BHA); mitogen-activated protein kinases (MAPKs); Nrf2; tert-butylhydroquinone (tBHQ);

    机译:丁基羟基茴香醚(BHA);促分裂原激活蛋白激酶(MAPK);Nrf2;叔丁基对苯二酚(tBHQ);

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