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Liposomal delivery of ferrous chlorophyllin: A novel third generation photosensitizer for in vitro PDT of melanoma

机译:叶绿素亚铁的脂质体递送:用于黑色素瘤体外PDT的新型第三代光敏剂

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摘要

Background: Cutaneous melanoma (CM) has substantially increased among Caucasian populations in the past few decades. This increased the number of CM deaths throughout the world. Pigmentation of melanoma reduces the efficacy of photodynamic therapy (PDT). Third generation photosensitizers (PSs) are characterized by improved targeting to the diseased tissue and reduced systemic side effects. This study is directed towards synthesis and characterization of liposomes encapsulating sodium ferrous chlorophyllin (Fe-CHL) and assessing its efficacy as a PS in PDT of melanoma.
机译:背景:在过去的几十年中,白种人中的皮肤黑色素瘤(CM)大量增加。这增加了全世界的CM死亡人数。黑色素瘤的色素沉着降低了光动力疗法(PDT)的功效。第三代光敏剂(PSs)的特征是针对患病组织的靶向性得到改善,全身副作用减少。这项研究的目的是封装和封装叶绿素亚铁钠(Fe-CHL)的脂质体,并评估其作为黑色素瘤PDT中PS的功效。

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