Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis

Ogihara Kumi; Isomoto Hajime; Kurumi Hiroki; Kanda Tsutomu; Hashisako Mikiko; Tabata Kazuhiro; Ishii Hiroyuki; Ohnita Ken; Yamaguchi Naoyuki; Akazawa Yuko; Matsushima Kayoko; Takeshima Fuminao; Kunizaki Masaki; Hidaka Shigekazu; Nanashima Atsushi; Fukuoka Junya; Nagayasu Takeshi; Nakao Kazuhiko

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Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis

机译：卟啉原氧化酶的表达与5-氨基乙酰丙酸介导的光动力诊断与上消化道癌的检测有关

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Background: 5-Aminolevulinic acid is a precursor of photosensitizing protoporphyrin IX and has been applied for photodynamic diagnosis of brain and bladder tumors with few side effects. Although most upper gastrointestinal tumors can be detected during photodynamic diagnosis, some tumors containing signet-ring cells cannot be visualized. Here, we aimed to assess whether proteins involved in the absorbance, activation, and turnover of protoporphyrin IX altered the fluorescence signal in gastric cancer.

机译：背景：5-氨基乙酰丙酸是光敏原卟啉IX的前体，已被用于脑和膀胱肿瘤的光动力学诊断，几乎没有副作用。尽管在光动力诊断过程中可以检测到大多数上消化道肿瘤，但是某些包含印戒细胞的肿瘤无法可视化。在这里，我们旨在评估参与原卟啉IX的吸收，激活和更新的蛋白质是否改变了胃癌中的荧光信号。

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来源
《Photodiagnosis and Photodynamic Therapy》 |2017年第9期|15-21|共7页
作者
Ogihara Kumi; Isomoto Hajime; Kurumi Hiroki; Kanda Tsutomu; Hashisako Mikiko; Tabata Kazuhiro; Ishii Hiroyuki; Ohnita Ken; Yamaguchi Naoyuki; Akazawa Yuko; Matsushima Kayoko; Takeshima Fuminao; Kunizaki Masaki; Hidaka Shigekazu; Nanashima Atsushi; Fukuoka Junya; Nagayasu Takeshi; Nakao Kazuhiko;
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作者单位

Nagasaki Univ, Grad Sch Biomed Sci, Dept Gastroenterol & Hepatol, Nagasaki, Japan;

Tottori Univ, Div Med & Clin Sci, Dept Multidisciplinary Internal Med, Fac Med, 36-1 Nishicho, Yonago, Tottori 6838504, Japan;

Tottori Univ, Div Med & Clin Sci, Dept Multidisciplinary Internal Med, Fac Med, 36-1 Nishicho, Yonago, Tottori 6838504, Japan;

Tottori Univ, Div Med & Clin Sci, Dept Multidisciplinary Internal Med, Fac Med, 36-1 Nishicho, Yonago, Tottori 6838504, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Pathol, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Pathol, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Gastroenterol & Hepatol, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Gastroenterol & Hepatol, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Gastroenterol & Hepatol, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Gastroenterol & Hepatol, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Gastroenterol & Hepatol, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Gastroenterol & Hepatol, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Surg, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Surg, Nagasaki, Japan;

Univ Miyazaki, Div Hepatobiliary Pancreas Surg, Fac Med, Miyazaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Pathol, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Surg, Nagasaki, Japan;

Nagasaki Univ, Grad Sch Biomed Sci, Dept Gastroenterol & Hepatol, Nagasaki, Japan;

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正文语种 eng
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关键词
Photodynamic diagnosis; Early gastric carcinoma; Coproporphyrinogen III oxidase; Oligopeptide transporter-1;

机译：光动力学诊断;早期胃癌;卟啉原原Ⅲ氧化酶;寡肽转运蛋白1;

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1. Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase [J] . Deng-Fu Yang, Jeng-Woei Lee, Hsin-Ming Chen, Journal of the Formosan Medical Association =: Taiwan yi zhi . 2014,第2期

机译：甲氨蝶呤增强了5-氨基纤维素酸介导的光动力治疗诱导诱导人SCC4细胞杀死副卟啉氧化酶的上调性
2. 5-aminolevulinic acid-mediated photodynamic diagnosis using fluorescence ureterorenoscopy for urinary upper tract urothelial carcinoma : Preliminary prospective single centre trial [J] . Photodiagnosis and Photodynamic Therapy . 2020,第Mara期

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3. The utility of 5-aminolevulinic acid-mediated photodynamic diagnosis in the detection of intraoperative bile leakage [J] . Inoue Yoshihiro, Imai Yoshiro, Fujii Kensuke, The American Journal of Surgery . 2017,第6期

机译：5-氨基纤维酸介导的光动力学诊断在检测术中胆汁泄漏中的效用
4. Mechanism of enhanced responses after combination photodynamic therapy (cPDT) in carcinoma cells involves C/EBP-mediated transcriptional upregulation of the coproporphyrinogen oxidase (CPO) gene [C] . Sanjay Anand, Tayyaba Hasan, Edward V. Maytin SPIE Conference on Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy . 2013

机译：癌细胞组合光动力治疗（CPDT）后增强响应的机制涉及C / EBP介导的副卟啉氧化酶（CPO）基因的转录上调
5. Initial Characterization of ECOP Overexpression in Squamous Cell Carcinoma of the Upper Aero-digestive Tract. [D] . Baras, Alexander S. 2009

机译：上呼吸消化道鳞状细胞癌中ECOP过表达的初步特征。
6. The Utility of a Flexible Fluorescence-Cystoscope with a Twin Mode Monitor for the 5-Aminolevulinic Acid-Mediated Photodynamic Diagnosis of Bladder Cancer [O] . Hideo Fukuhara, Mitsuhiro Kureishi, Takeo Khoda, -1

机译：带有双模式监视器的柔性荧光膀胱镜在5-氨基乙酰丙酸介导的膀胱癌光动力诊断中的实用性
7. Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase [O] . Deng-Fu Yang, Jeng-Woei Lee, Hsin-Ming Chen, 2014

机译：甲氨蝶呤通过上调粪卟啉原氧化酶增强5-氨基乙酰丙酸介导的光动力疗法诱导的人sCC4细胞杀伤
8. Photodynamic Therapy Oxidative Stress as a Molecular Switch Controlling Therapeutic Gene Expression for the Treatment of Locally Recurrent Breast Carcinoma [R] . Gomer, C. J. 2002

机译：光动力疗法氧化应激作为分子开关控制治疗基因表达治疗局部复发性乳腺癌

Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis

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