Photochemical internalization (PCI) of bleomycin is equally effective in two dissimilar leiomyosarcoma xenografts in athymic mice

Sellevold Simen; Peng Qian; Fremstedal Ane Sofie Viset; Berg Kristian

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Photochemical internalization (PCI) of bleomycin is equally effective in two dissimilar leiomyosarcoma xenografts in athymic mice

机译：博来霉素的光化学内在化（PCI）在无胸腺小鼠的两种异种平滑肌肉肉瘤异种移植中同样有效

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Background: Photochemical internalization (PCI) is a novel technique for delivery of active macromolecules into cancerous cells, via light activation of a specific photosensitizer and a low dose systemic drug. Numerous pre-clinical studies and one clinical trial have confirmed the treatment potential in carcinomas. Soft tissue sarcomas are rare and generally resistant to radio- and chemotherapy. Due to treatment resistance and surgical morbidity in sarcoma care, we seek to increase knowledge on PCI effects in sarcomas by studying two different, but closely related leiomyosarcomas.

机译：背景：光化学内在化（PCI）是一种通过特定光敏剂和低剂量全身性药物的光活化将活性大分子递送至癌细胞的新技术。大量的临床前研究和一项临床试验已经证实了在癌症中的治疗潜力。软组织肉瘤很少见，通常对放射和化学疗法有抵抗力。由于肉瘤护理中的治疗耐药性和手术发病率，我们试图通过研究两种不同但密切相关的平滑肌肉瘤来增加对肉瘤中PCI效果的认识。

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来源
《Photodiagnosis and Photodynamic Therapy》 |2017年第12期|95-106|共12页
作者
Sellevold Simen; Peng Qian; Fremstedal Ane Sofie Viset; Berg Kristian;
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作者单位

Oslo Univ Hosp, Div Orthopaed Surg, Oslo, Norway;

Oslo Univ Hosp, Norwegian Radium Hosp, Dept Pathol, Oslo, Norway;

Oslo Univ Hosp, Norwegian Radium Hosp, Inst Canc Res, Dept Radiat Biol, N-0379 Oslo, Norway;

Oslo Univ Hosp, Norwegian Radium Hosp, Inst Canc Res, Dept Radiat Biol, N-0379 Oslo, Norway;

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正文语种 eng
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关键词
Photochemical internalization; Bleomycin; Sarcoma; Vascular shutdown; In vivo;

机译：光化学内在化;博来霉素;肉瘤;血管关闭;体内;

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专利

1. Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin [J] . Olsen Cathrine Elisabeth, Sellevold Simen, Theodossiou Theodossis, Photodiagnosis and Photodynamic Therapy . 2017,第deca期

机译：肉瘤模型中基因型和表型差异对博来霉素光化学内在化（PCI）结果的影响
2. Importance of the Galalpha1-3Gal antigen in discordant islet xenotransplantation: immunosuppression, which inhibits porcine islet xenograft rejection in ordinary mice, is equally effective in Gal-knockout mice. [J] . Wennberg L, Song Z, Bennet W, Transplantation: Official Journal of the Transplantation Society . 2004,第8期

机译：Galalpha1-3Gal抗原在异种胰岛异种移植中的重要性：免疫抑制在普通小鼠中抑制猪胰岛异种移植排斥，在Gal敲除小鼠中同样有效。
3. Importance of the Gal alpha1-3 Gal antigen in discordant islet xenotransplantation: immunosuppression, which inhibits porcine islet xenograft rejection in ordinary mice, is equally effective in Gal-knockout mice. [J] . Wennberg L, Song Z, Bennet W, Transplantation: Official Journal of the Transplantation Society . 2004,第8期

机译：Galα1-3Gal抗原在异种胰岛异种移植中的重要性：免疫抑制在普通小鼠中抑制猪胰岛异种移植排斥，在Gal敲除小鼠中同样有效。
4. Photochemical internalization enhances the efficacy of bleomycin in malignant glioma cells [C] . Steen J. Madsen, Joseph W. Blickenstaff, Van Vo, Photonic therapeutics and diagnostics V . 2009

机译：光化学内在化增强博来霉素在恶性神经胶质瘤细胞中的功效
5. The effect of flaxseed lignan and oil, and sesame lignan on the growth of human estrogen receptor-positive breast tumour xenografts (MCF-7) in athymic mice. [D] . Truan, Jennifer S. 2009

机译：亚麻籽木脂和油以及芝麻木脂对无胸腺小鼠中人雌激素受体阳性乳腺异种移植物（MCF-7）生长的影响。
6. Photochemical internalization of bleomycin for glioma treatment [O] . Marlon S. Mathews, Joseph W. Blickenstaff, En-Chung Shih, 2012

机译：博来霉素的光化学内在化治疗神经胶质瘤
7. Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin [O] . Cathrine Elisabeth Olsen, Simen Sellevold, Theodossis Theodossiou, 2017

机译：肉瘤模型基因型和表型差异对博莱霉素光化学内化（PCI）结果的影响
8. Photodynamic Therapy of Human Malignant Melanoma Xenografts in Athymic Nude Mice [R] . Nelson, J. S., McCullough, J. L., Berns, M. W. 1981

机译：人恶性黑色素瘤异种移植物在无胸腺裸鼠体内的光动力学治疗

Photochemical internalization (PCI) of bleomycin is equally effective in two dissimilar leiomyosarcoma xenografts in athymic mice

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