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5-Aminolevulinic acid-based photodynamic therapy of chordoma: In vitro experiments on a human tumor cell line

机译:基于5-氨基乙酰丙酸的脊索瘤光动力疗法:在人类肿瘤细胞系上的体外实验

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摘要

Background: Chordomas are very rare tumors of the skull base and the sacrum. They show infiltrating and destructive growth and are known to be chemo- and radio-resistant. After surgical resection, the recurrence rate is high and overall survival limited. As current adjuvant treatments are ineffective, new treatment concepts are urgently needed. 5-aminolevulinic acid-based photodynamic therapy (5-ALA based PDT) showed promising results for malignant gliomas. However, it is unknown so far, whether chordomas accumulate protoporphyrin IX (PPIX) after application of 5-ALA and whether they are sensitive to subsequent 5-ALA based PDT.
机译:背景:脊索瘤是颅底和ac骨非常罕见的肿瘤。它们显示出浸润性和破坏性生长,并且已知具有化学和放射抗性。手术切除后,复发率高,总生存期有限。由于当前的辅助治疗无效,因此迫切需要新的治疗方案。基于5-氨基乙酰丙酸的光动力疗法(基于5-ALA的PDT)对恶性神经胶质瘤显示出令人鼓舞的结果。但是,到目前为止,尚不清楚应用5-ALA后脊索瘤是否积聚原卟啉IX(PPIX),以及它们是否对随后的基于5-ALA的PDT敏感。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2017年第12期|111-115|共5页
  • 作者单位

    Heinrich Heine Univ, Med Fac, Dept Neurosurg, Moorenstr 5, D-40225 Dusseldorf, Germany;

    Heinrich Heine Univ, Med Fac, Dept Neurosurg, Moorenstr 5, D-40225 Dusseldorf, Germany;

    Heinrich Heine Univ, Med Fac, Inst Transplantat Diagnost & Cell Therapeut, Moorenstr 5, D-40225 Dusseldorf, Germany;

    Heinrich Heine Univ, Med Fac, Dept Neurosurg, Moorenstr 5, D-40225 Dusseldorf, Germany;

    Heinrich Heine Univ, Med Fac, Dept Neurosurg, Moorenstr 5, D-40225 Dusseldorf, Germany;

    Heinrich Heine Univ, Med Fac, Dept Neurosurg, Moorenstr 5, D-40225 Dusseldorf, Germany;

    Heinrich Heine Univ, Med Fac, Inst Transplantat Diagnost & Cell Therapeut, Moorenstr 5, D-40225 Dusseldorf, Germany;

    Heinrich Heine Univ, Med Fac, Dept Neurosurg, Moorenstr 5, D-40225 Dusseldorf, Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    5-ALA; Adjuvant; Chordoma; PDT; Photodynamic therapy; Skull base;

    机译:5-ALA;佐剂;脊索瘤;PDT;光动力疗法;颅底;

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