Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ

Ribeiro de Souza Ana Luiza; LaRochelle Ethan; Marra Kayla; Gunn Jason; Davis Scott C.; Samkoe Kimberley S.; Chapman M. Shane; Maytin Edward V.; Hasan Tayyaba; Pogue Brian W.

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Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ

机译：利用光物理，生化和生物损伤指标的生物标志物评估日光和低剂量光动力疗法的疗效

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Background: Sunlight can activate photodynamic therapy (PDT), and this is a proven strategy to reduce pain caused byconventional PDT treatment, but assessment of this and other alternative low dose rate light sources, and their efficacy, has not been studied in an objective, controlled pre-clinical setting. This study used three objective assays to assess the efficacy of different PDT treatment regimens, using PpIX fluorescence as a photophysical measure, STAT3 cross-linking as a photochemical measure, and keratinocyte damage as a photo biological measure.

机译：背景：阳光可以激活光动力疗法（PDT），这是减轻常规PDT治疗所引起的疼痛的一种行之有效的策略，但是尚未对此目标和其他低剂量率替代光源及其功效进行评估，受控的临床前设置。这项研究使用三种客观测定法来评估不同的PDT治疗方案的功效，以PpIX荧光作为光物理方法，STAT3交联作为光化学方法，以及角质形成细胞损伤作为光生物方法。

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《Photodiagnosis and Photodynamic Therapy》 |2017年第12期|227-233|共7页
作者
Ribeiro de Souza Ana Luiza; LaRochelle Ethan; Marra Kayla; Gunn Jason; Davis Scott C.; Samkoe Kimberley S.; Chapman M. Shane; Maytin Edward V.; Hasan Tayyaba; Pogue Brian W.;
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作者单位

Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA;

Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA;

Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA;

Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA;

Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA;

Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA;

Dartmouth Coll, Geisel Sch Med, Dept Surg, 1 Med Ctr Dr, Lebanon, NH 03756 USA;

Cleveland Clin, Dept Biomed Engn, Cleveland, OH 44195 USA;

Harvard Med Sch, Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA;

Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA;

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正文语种 eng
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关键词
"daylight PDT"; Aminolaevulinic acid; STAT3 cross-linking; Damage to keratinocytes; PpIX-weighted light dose; Photodynamic;

机译：“日光PDT”;氨基戊酸;STAT3交联;对角质形成细胞的损害;PpIX加权光剂量;光动力学;

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6. Assessing daylight low-light photodynamic therapy efficacy using biomarkers of photophysical biochemical and biological damage metrics in situ [O] . Ana Luiza Ribeiro de Souza, Ethan LaRochelle, Kayla Marra, -1

机译：使用原位光物理生化和生物损伤指标的生物标志物评估日光和弱光光动力疗法的疗效
7. Assessing daylight low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ [O] . Ana Luiza Ribeiro de Souza, Ethan LaRochelle, Kayla Marra, 2017

机译：评估白天和低剂量率光动力治疗疗效，使用光药，生化和生物损伤度量的生物标志物原位

Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ

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