Dependence of damage within 10 min to myocardial cells by a photodynamic reaction with a high concentration of talaporfin sodium outside cells in vitro on parameters of laser irradiation

Ogawa Emiyu; Ito Arisa; Arai Tsunenori

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Dependence of damage within 10 min to myocardial cells by a photodynamic reaction with a high concentration of talaporfin sodium outside cells in vitro on parameters of laser irradiation

机译：高浓度他拉泊芬钠细胞外光动力反应对心肌细胞在10分钟内的损伤依赖于激光辐照参数

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Background: To investigate the immediate occurrence of irreparable severe damage to myocardial cells up to 10 min after a photodynamic reaction with a high concentration of photosensitizer outside cells, we measured the damage response time and the parameters that govern the response time via rat myocardial Ca2+ concentration. In our proposed method for catheter ablation of tachyarrhythmia by photodynamic reaction, there are two components to the electrical conduction block: an immediate electrical conduction block of several tens of seconds to several minutes, and a permanent electrical conduction block.

机译：背景：为了研究在高浓度光敏剂外细胞的光动力反应后长达10分钟的心肌细胞立即发生不可修复的严重损伤的情况，我们测量了损伤反应时间以及通过大鼠心肌Ca2 +浓度控制反应时间的参数。在我们提出的通过光动力反应消融快速性心律失常的方法中，电传导阻滞有两个组成部分：数十秒到几分钟的即时电传导阻滞和永久性电传导阻滞。

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《Photodiagnosis and Photodynamic Therapy》 |2016年第9期|1-5|共5页
作者
Ogawa Emiyu; Ito Arisa; Arai Tsunenori;
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作者单位

Keio Univ, Grad Sch Sci & Technol, Sch Fundamental Sci & Technol, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan;

Keio Univ, Grad Sch Sci & Technol, Sch Fundamental Sci & Technol, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan;

Keio Univ, Grad Sch Sci & Technol, Sch Fundamental Sci & Technol, Kohoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan;

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正文语种 eng
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Talaporfin sodium; Myocardial cell; Extracellular photodynamic reaction; Response time; Catheter ablation;

机译：他拉泊芬钠;心肌细胞;细胞外光动力反应;响应时间;导管消融;

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专利

1. Comparison of myocardial cell survival 2 h and 24 h after extracellular talaporfin sodium-induced photodynamic reaction [J] . Ogawa Emiyu, Machida Naoki, Ito Arisa, Photodiagnosis and Photodynamic Therapy . 2016,第Mara期

机译：细胞外他拉泊芬钠诱导的光动力反应后2 h和24 h心肌细胞存活的比较
2. Photosensitization reaction-induced acute electrophysiological cell response of rat myocardial cells in short loading periods of talaporfin sodium or porfimer sodium [J] . Ito A., Kimura T., Miyoshi S., Photochemistry and Photobiology: An International Journal . 2011,第1期

机译：他拉泊芬钠或porfimer钠在短时间内光敏反应诱导大鼠心肌细胞的急性电生理细胞反应
3. Evaluation of oxygen consumption of culture medium and in vitro photodynamic effect of talaporfin sodium in lung tumor cells. [J] . Tomioka Y, Kushibiki T, Awazu K Photomedicine and laser surgery . 2010,第3期

机译：评价培养基的耗氧量和他拉泊芬钠在肺肿瘤细胞中的体外光动力效应。
4. Extracellular talaporfin sodium-induced photosensitization reaction with various albumin animal species on myocardial cells in vitro [C] . Emiyu Ogawa, Tsunenori Arai Optical interactions with tissue and cells XXVIII . 2017

机译：细胞外他拉泊芬钠诱导的各种白蛋白动物对心肌细胞的光敏反应
5. DNA Damage Responses of Mitotic Cells Following Laser Micro-irradiation. [D] . Gomez Godinez, Veronica. 2012

机译：激光微辐照后有丝分裂细胞的DNA损伤反应。
6. Low-density lipoprotein receptor expression is involved in the beneficial effect of photodynamic therapy using talaporfin sodium on gastric cancer cells [O] . Tsutomu Kanda, Takaaki Sugihara, Tomoaki Takata, -1

机译：低密度脂蛋白受体表达参与他拉泊芬钠对胃癌细胞的光动力治疗的有益作用
7. Dependence of damage within 10 min to myocardial cells by a photodynamic reaction with a high concentration of talaporfin sodium outside cells in vitro on parameters of laser irradiation [O] . Emiyu Ogawa, Arisa Ito, Tsunenori Arai 2016

机译：在激光照射参数的体外光动力反应在10分钟内通过光动力反应在体外具有高浓度的Talaporfin钠钠的光动力反应在激光照射参数上的光动力反应依赖于心肌动力学细胞

Dependence of damage within 10 min to myocardial cells by a photodynamic reaction with a high concentration of talaporfin sodium outside cells in vitro on parameters of laser irradiation

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