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Photodynamic therapy for onychomycosis: A systematic review

机译：光动力疗法治疗灰指甲：系统评价

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Other than a cosmetic concern, Onychomycosis is also a prevalent nail disease, which is extremely difficult to treat, and sometimes is refractory to conventional therapy. Moreover, many patients are not eligible to take oral antifungals owing to polypharmacy and comorbidities. Systemic side effects seen with oral antifungals have lead to patient nonadherence and adverse events. Therefore, newer therapies are being investigated for onychomycosis that would be free of systemic complications posed by oral therapy. Photodynamic therapy (PDT) is one of those being currently studied, which involves the use of photosensitizer and a light source to excite the photosensitizer to generate reactive oxygen species. The present review will put some light on PDT as an upcoming treatment modality for onychomycosis. We performed a systematic review of the literature to find the articles relevant to the use of PDT for onychomycosis. From the primary search of 43 articles, 17 papers are included in this review. (C) 2016 Elsevier B.V. All rights reserved.
机译：除美容方面外，甲癣也是一种普遍的指甲疾病，极难治疗，有时对传统疗法无能为力。此外，由于多药房和合并症，许多患者没有资格服用口服抗真菌药。口服抗真菌药引起的全身性副作用导致患者不依从和不良事件。因此，正在研究针对灰指甲的新疗法，这种疗法将不会出现口服疗法引起的全身性并发症。光动力疗法（PDT）是目前正在研究的一种，涉及使用光敏剂和光源来激发光敏剂以产生活性氧。本综述将对PDT作为甲癣的一种即将来临的治疗方式给予一些启示。我们对文献进行了系统的综述，以查找与使用PDT治疗甲癣相关的文章。在对43篇文章的初步搜索中，本评价包括17篇论文。 （C）2016 Elsevier B.V.保留所有权利。

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