• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Clinical, biochemical and histological study of the effect of antimicrobial photodynamic therapy on oral mucositis induced by 5-fluorouracil in hamsters
【24h】

Clinical, biochemical and histological study of the effect of antimicrobial photodynamic therapy on oral mucositis induced by 5-fluorouracil in hamsters

机译：抗菌光动力疗法对5-氟尿嘧啶引起的仓鼠口腔黏膜炎影响的临床，生化和组织学研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Oral mucositis (OM) is a debilitating side effect of chemotherapy, which can be relieved by phototherapy. Antimicrobial photodynamic therapy (aPDT) may be used for the treatment of OM, when infection is present. However, there are no studies showing that aPDT affects tissue repair process when used in the treatment of lesions caused by OM. This work aims to evaluate the effect of aPDT in healing OM induced by 5-Fluorouracil (5-FU). Two hundred forty-five hamsters were divided into two groups, control (C) and experimental, which were subdivided into 4 subgroups (Ch, ChP, ChL, aPDT). C group received only the vehicle of chemotherapy and anesthesia, whereas all animals of the experimental groups received anesthesia and chemotherapy agent 5-FU to induce OM. Ch group received no OM treatment; ChP group received an application of methylene blue (MB) 0.01%; ChL received irradiation with low-power-laser (LPL-660 nm/120J/cm(2)/40mW/4.4J per point); and aPDT received MB and LPL irradiation. OM Clinical severity were daily assessed by a blinded examiner. The animals were sacrificed after 5, 7 and 10 days of experiment and their oral mucosa were removed for biochemical (enzymatic activity of SOD and catalase) and histological analyzes (light microscopy). After statistical analysis was performed, results showed that aPDT reduced the severity of OM on the tenth day of the experiment, when compared to the initial OM score (p< 0.05), as well as increased keratinization with organized collagen deposition in the lamina propria. In conclusion, aPDT can be safely used in animals with infected OM because it does not affect lesion-repairing processes. (c) 2014 Elsevier B.V. All rights reserved.
机译：口腔粘膜炎（OM）是化学疗法的虚弱副作用，可通过光疗缓解。当存在感染时，可以使用抗微生物光动力疗法（aPDT）来治疗OM。然而，尚无研究表明，aPDT在用于治疗由OM引起的病变时会影响组织修复过程。这项工作旨在评估aPDT在5-氟尿嘧啶（5-FU）诱导的OM愈合中的作用。将245只仓鼠分为两组，对照组（C）和实验组，分为4个亚组（Ch，ChP，ChL，aPDT）。 C组仅接受化疗和麻醉的载体，而实验组的所有动物均接受麻醉和化疗剂5-FU诱导OM。 Ch组未接受OM治疗； ChP组接受了0.01％的亚甲基蓝（MB）施用； ChL接受低功率激光（每点LPL-660 nm / 120J / cm（2）/40mW/4.4J）照射; aPDT接受了MB和LPL照射。 OM临床严重性每天由盲人检查者进行评估。在实验的第5、7和10天后处死动物，并去除其口腔粘膜进行生化（SOD和过氧化氢酶的酶活性）和组织学分析（光学显微镜）。经过统计分析后，结果显示，与初始OM评分相比（p <0.05），aPDT在实验的第10天降低了OM的严重程度，并增加了角质化以及固有层固有胶原沉积。总之，aPDT可以安全地用于感染了OM的动物，因为它不影响病变修复过程。 （c）2014 Elsevier B.V.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号