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Fluorescence spectroscopy for the detection of potentially malignant disorders and squamous cell carcinoma of the oral cavity

机译：荧光光谱法检测潜在的恶性疾病和口腔鳞状细胞癌

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摘要

Oral cancer is a public health problem with relevant incidence in the world population. The affected patient usually presents advanced stage disease and the consequence of this delay is a reduction in survival rates. Given this, it is essential to detect oral cancer at early stages. Fluorescence spectroscopy is a non-invasive diagnostic tool that can improve cancer detection in real time. It is a fast and accurate technique, relatively simple, which evaluates the biochemical composition and structure using the tissue fluorescence spectrum as interrogation data. Several studies have positive data regarding the tools for differentiating between normal mucosa and cancer, but the difference between cancer and potentially malignant disorders is not clear. The aim of this study was to evaluate the efficacy of fluorescence spectroscopy in the discrimination of normal oral mucosa, oral cancer, and potentially malignant disorders. The fluorescence spectroscopy was evaluated in 115 individuals, of whom 55 patients presented oral squamous cell carcinoma, 30 volunteers showing normal oral mucosa, and 30 patients having potentially malignant disorders. The spectra were classified and compared to histopathology to evaluate the efficiency in diagnostic discrimination employing fluorescence. In order to classify the spectra, a decision tree algorithm (C4.5) was applied. Despite of the high variance observed in spectral data, the specificity and sensitivity obtained were 93.8% and 88.5%, respectively at 406 nm excitation. These results point to the potential use of fluorescence spectroscopy as an important tool for oral cancer diagnosis and potentially malignant disorders.
机译：口腔癌是一种公共卫生问题，在世界人口中发病率与此有关。受影响的患者通常表现出晚期疾病，这种延迟的结果是存活率降低。鉴于此，早期检测口腔癌至关重要。荧光光谱法是一种非侵入性的诊断工具，可以实时改善癌症检测。这是一种快速且准确的技术，相对简单，它使用组织荧光光谱作为询问数据来评估生化成分和结构。几项研究在区分正常粘膜和癌症的工具方面获得了积极的数据，但是尚不清楚癌症与潜在恶性疾病之间的区别。这项研究的目的是评估荧光光谱在区分正常口腔粘膜，口腔癌和潜在恶性疾病中的功效。评估了115位个体的荧光光谱，其中55例出现口腔鳞状细胞癌，30例表现出正常口腔粘膜的志愿者以及30例可能患有恶性疾病的患者。将光谱分类并与组织病理学比较，以评估使用荧光的诊断判别效率。为了对光谱进行分类，应用了决策树算法（C4.5）。尽管在光谱数据中观察到很大的差异，但在406 nm激发下获得的特异性和灵敏度分别为93.8％和88.5％。这些结果表明荧光光谱法有可能用作口腔癌诊断和潜在恶性疾病的重要工具。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2014年第2期|82-90|共9页
  • 作者

    Ana Lucia Noronha Francisco; Wagner Rafael Correr; Luciane Hiramatsu Azevedo; Vivian Galletta Kern; Clovis Antonio Lopes Pinto; Luiz Paulo Kowalski; Cristina Kurachi;

  • 作者单位

    Department of Oral Diagnosis, School of Dentistry of Piracicaba, University of Campinas (UNICAMP), Av. Limeira 901, Piracicaba 13414-018, Sao Paulo, Brazil;

    Department of Physics and Materials Science, Physics Institute of Sao Carlos, University of Sao Paulo (USP), Av. Trabalhador Sao-Carlense 400, Sao Carlos 13566-590, Sao Paulo, Brazil;

    Special Laboratory of Laser in Dentistry, School of Dentistry of Sao Paulo, University of Sao Paulo (USP), Cidade Universitaria, Sao Paulo 05508-000, Sao Paulo, Brazil;

    Special Laboratory of Laser in Dentistry, School of Dentistry of Sao Paulo, University of Sao Paulo (USP), Cidade Universitaria, Sao Paulo 05508-000, Sao Paulo, Brazil;

    Department of Pathology, A.C. Camargo Cancer Center, Antonio Prudente 211, Sao Paulo 01509-900, Sao Paulo, Brazil;

    Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center and the National Institute of Science and Technology in Oncogenomics (INCITO), Antonio Prudente 211, Sao Paulo 01509-900, Sao Paulo, Brazil;

    Department of Physics and Materials Science, Physics Institute of Sao Carlos, University of Sao Paulo (USP), Av. Trabalhador Sao-Carlense 400, Sao Carlos 13566-590, Sao Paulo, Brazil;

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  • 关键词

    Squamous cell carcinoma; Fluorescence spectroscopy; Early diagnosis; Potentially malignant disorders; Oral cavity;

    机译：鳞状细胞癌;荧光光谱法;早期诊断;潜在的恶性疾病;口腔;

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