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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >A commentary on the role of skin temperature on the effectiveness of ALA-PDT in Dermatology
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A commentary on the role of skin temperature on the effectiveness of ALA-PDT in Dermatology

机译：皮肤温度对ALA-PDT在皮肤病学中的作用的评论

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摘要

The review of several studies indicates clearly that improving ALA-PDT of skin lesions might be achieved by elevating the skin temperature during the ALA application. Several mechanisms could be responsible: a better ALA uptake and/or an higher PpIX production into cells due to an improved enzymatic process, mainly due to the increased activity of ferrochelatase. Vasodilatation of skin vessels could also increase the oxygen supply and consequently enhances the generation of singlet oxygen, and other cytotoxic species. Different techniques can be used to perform an elevation of skin temperature: IRA, heating blanket, etc. At last, skin heating could increase the penetration (depth) of ALA into the skin, which thereby may increase PplX production (in deeper layers) in the skin. This could represent an interesting approach to improving ALA-PDT of nodular BCC and other skin lesions.
机译：多项研究的回顾清楚地表明，改善皮肤损伤的ALA-PDT可以通过在ALA应用过程中升高皮肤温度来实现。可能有几种机理：主要是由于铁螯合酶活性的提高，由于改善了酶促过程，导致了更好的ALA摄取和/或更高的PpIX进入细胞的产生。皮肤血管的血管舒张还可以增加氧气的供应，从而增强单线态氧气和其他细胞毒性物质的产生。可以使用不同的技术来升高皮肤温度：IRA，加热毯等。最后，皮肤加热可以增加ALA进入皮肤的渗透（深度），从而可以增加PplX的产生（在更深层）。皮。这可能是改善结节性BCC和其他皮肤病变的ALA-PDT的有趣方法。

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