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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis
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Evaluation of the progression rate of atrophy lesions in punctate inner choroidopathy (PIC) based on autofluorescence analysis

机译：基于自发荧光分析的点状内脉络膜病变（PIC）萎缩性病变进展率评估

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Purpose: To investigate the autofluorescence (AF) characteristics of punctate inner choroidopathy (PIC) and to evaluate the progression rate of retinal pigment epithelium (RPE) atrophy lesions in PIC using confocal scanning laser ophthalmoscopy. Methods: Twenty-two eyes of 14 PIC cases and 21 eyes of 21 non-proliferative diabetic retinopa-thy (NPDR) cases which received retinal coagulation as a control group were enrolled in this study. Enhanced depth imaging optical coherence tomography (EDI-OCT) and AF were recorded from all patients at 18 months follow-up. The RPE atrophy areas of PIC and laser scars in NPDR were analyzed using the Region Finder software of the Heidelberg Eye Explorer. This software allows direct export of AF images from the database and semi-automated detection of atrophic areas by shadow correction, vessel detection, and selection of seed points. Results: At baseline, both hyperfluorescence and hypofluorescence were observed in the lesions of PIC eyes with a focal elevation of RPE and corresponding disruption of the ellipsoid region of the inner segment ellipsoid zone (EZ). In contrast, hypo-AF was detected when there was a lack of RPE. The mean progression rate of RPE atrophy in PIC and NPDR were 3.735 mm~2/year (0.056-0.545) and 0.127 mm~2/year (0.015-0.466), respectively. Compared with the atrophy area in the last visit, the progression rate in PIC was significantly greater than that in NPDR (Z= 5.615, P＜0.0001). Conclusions: The results of AF reflect the status of PIC and the progression rate of RPE atrophy in PIC, which can be used to predict the proaress of PIC noninvasively.
机译：目的：研究共点扫描激光检眼镜在点状内脉络膜病变（PIC）的自发荧光（AF）特征，并评估PIC中视网膜色素上皮（RPE）萎缩性病变的进展速度。方法：将14例PIC患者的22只眼和21例非增殖性糖尿病性视网膜病变（NPDR）的21只眼作为对照组进行了研究。在18个月的随访中记录了所有患者的增强深度成像光学相干断层扫描（EDI-OCT）和AF。使用Heidelberg Eye Explorer的Region Finder软件分析了NPDR中PIC的RPE萎缩区域和激光疤痕。该软件可以从数据库直接导出AF图像，并通过阴影校正，血管检测和种子点选择来半自动检测萎缩区域。结果：在基线时，在PIC眼的病变中同时观察到了高荧光和低荧光，伴有RPE的局部增高，并相应地破坏了内段椭圆体区域（EZ）的椭圆体区域。相比之下，缺乏RPE时会检测到AF不足。 PIC和NPDR中RPE萎缩的平均进展率分别为3.735 mm〜2 /年（0.056-0.545）和0.127 mm〜2 /每年（0.015-0.466）。与上次访视的萎缩区域相比，PIC的进展率显着高于NPDR（Z = 5.615，P ＜0.0001）。结论：AF的结果反映了PIC的状态和RPE萎缩在PIC中的进展速度，可用于无创预测PIC的发生率。

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