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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Fluorescence sensing system by Soret-band LED light excitation for estimating relative talaporfin sodium concentration in skin
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Fluorescence sensing system by Soret-band LED light excitation for estimating relative talaporfin sodium concentration in skin

机译：Soret-band LED光激发的荧光传感系统，用于估算皮肤中他拉泊芬钠的相对浓度

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摘要

The purpose of this study is to establish a sensing system to estimate relative talaporfin sodium concentration in skin to evaluate the risk of skin photosensitivity after photo-dynamic therapy (PDT) using percutaneous fluorescence spectroscopy. A prototype fluorescence sensing probe was made using a pair of 5-cm-long diffuse tips of plastic optical fibers for excitation light irradiation and fluorescence collection. Talaporfin sodium (2.5 mg/kg) was intravenously administrated to three pigs, and the talaporfin sodium concentration in plasma was measured. The fluorescence sensing probe was attached to the skin and excited by a LED light with a peak wavelength of 409 ± 16 nm to obtain the mean area of the talaporfin sodium fluorescence spectral peak (S_(fluo). The time history of the talaporfin sodium concentration in tissue was estimated using a two-compartment pharmacokinetic model. The time history of S_(fluo) was described as a composite function of the time history of the measured talaporfin sodium concentration in plasma and that of the estimated concentration in tissue as a double exponential decay function. The relative talaporfin sodium concentration in tissue and the relative contributions of fluorescence from tissue and plasma to S_(fluo) were estimated by the fluorescence system with the numerical pharmacokinetic model. Results also show that tissue compression equivalent to venous pressure might be effective to suppress the contribution of talaporfin sodium fluorescence in plasma.
机译：这项研究的目的是建立一种传感系统，以估计皮肤中他拉泊芬钠的相对浓度，以评估使用经皮荧光光谱法进行光动力治疗（PDT）后皮肤光敏性的风险。使用一对5厘米长的塑料光纤漫射尖端制作了原型荧光传感探针，用于激发光照射和荧光收集。向三只猪静脉内施用他拉泊芬钠（2.5 mg / kg），并测量血浆中他拉泊芬钠的浓度。将荧光传感探针附着在皮肤上，并用峰值波长为409±16 nm的LED光激发，以获得他拉泊芬钠荧光光谱峰的平均面积（S_（fluo）。使用两室药代动力学模型估算组织中的S_（fluo）的时间历史，该时间历史描述为血浆中他拉泊芬钠浓度的测量历史与组织中估算浓度的时间历史的复合函数（双指数）用数值药代动力学模型通过荧光系统估算了组织中他拉泊芬钠的相对浓度以及组织和血浆中荧光对S_（fluo）的相对贡献，结果还表明与静脉压相当的组织压迫可能是有效的。抑制他拉泊芬钠荧光在血浆中的作用。

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