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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Tumor-selective near-infrared photodynamic therapy with novel indocyanine green-loaded nanocarrier delays paralysis in rats with spinal metastasis
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Tumor-selective near-infrared photodynamic therapy with novel indocyanine green-loaded nanocarrier delays paralysis in rats with spinal metastasis

机译：新型吲哚菁绿载纳米载体的肿瘤选择性近红外光动力疗法可延缓脊髓转移大鼠的瘫痪

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摘要

Background: Although recent advances in surgery have improved the quality of life of patients with spinal metastasis, local recurrence is still relatively common. Therefore, there is an urgent need for new surgical treatment options for metastatic spinal cancer. We previously described a novel nanocarrier loaded with indocyanine green (ICG), ICG-lactosome which exhibits tumor selectivity and is a potential near-infrared (NIR) fluorescence imaging agent for the diagnosis of spinal metastasis. The purpose of this study was to investigate the therapeutic effects of tumor-selective photodynamic therapy (PDT) with ICG-lactosome and NIR light irradiation in a rat model of spinal metastasis. Methods: Twenty-one Fischer 344 rats each with a single spinal metastasis in the L6 vertebral body were divided into 3 treatment groups: PDT with a low-concentration ICG-lactosome injection (6 rats), PDT with high-concentration ICG-lactosome injection (7 rats), and a group without ICG-lactosome injection (8 rats). All the animals received local NIR light irradiation with a total energy of 5 J (0.5 W for 10 s). Results: Both the PDT groups injected with ICG-lactosome showed delayed deterioration of hind-limb paralysis compared with the group without ICG-lactosome. Conclusion: This modified PDT procedure could be an effective local treatment for spinal metastasis.
机译：背景：尽管最近的外科手术进展改善了脊柱转移患者的生活质量，但局部复发仍相对普遍。因此，迫切需要转移性脊柱癌的新的外科治疗选择。我们先前描述了一种新型的纳米载体，其中载有吲哚花青绿（ICG），ICG-乳球体，它具有肿瘤选择性，并且是诊断脊柱转移的潜在近红外（NIR）荧光成像剂。这项研究的目的是调查肿瘤选择性光动力疗法（PDT）的ICG乳胶体和近红外光照射在大鼠脊髓转移模型中的治疗效果。方法：二十一只Fischer 344只在L6椎体中有单个脊柱转移的大鼠被分为3个治疗组：低浓度ICG乳胶体注射的PDT（6只大鼠），高浓度ICG乳胶体注射的PDT （7只大鼠），和一组未注射ICG-乳胶体的大鼠（8只大鼠）。所有动物均接受局部NIR光照射，总能量为5 J（0.5 W，持续10 s）。结果：与未注射ICG-乳胶体的组相比，注射ICG-乳胶体的PDT组均显示后肢麻痹的延迟恶化。结论：这种改良的PDT方法可以有效地治疗脊柱转移。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2013年第4期|374-378|共5页
  • 作者

    Toru Funayama; Toshinori Tsukanishi; Isao Hara; Eiichi Ozeki; Masataka Sakane;

  • 作者单位

    Department of Orthopaedic Surg ery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan,Present address: Department of Orthopedic Surgery, Kenpoku Medical Center Takahagi Kyodo Hospital, 1006-9 Ageho-cho, Kamitetsuna,Takahagi, Ibaraki 318-0004, Japan;

    Department of Orthopaedic Surg ery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan;

    Technology Research Laboratory, Shimadzu Corporation, Japan;

    Technology Research Laboratory, Shimadzu Corporation, Japan;

    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, Japan;

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  • 正文语种 eng
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  • 关键词

    Photodynamic therapy; Indocyanine green; Nanocarrier; Spinal metastasis; Paralysis;

    机译：光动力疗法;吲哚花青绿;纳米载体脊柱转移;麻痹;

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