Spectral detection of sickle cell anemia and thalassemia

V. Masilamani; M.S. Al Salhi; S. Devanesan; Farjah H. AlGahtani; Khalid M. Abu-Salah; I. Ahamad; P. Agastian

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Spectral detection of sickle cell anemia and thalassemia

机译：镰状细胞贫血和地中海贫血的光谱检测

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Sickle cell disease (SCD) and thalassemia (Thal) are the most common inherited, autosomal, recessive blood disorders which lead to complications such as vasoocclusion and splenomegaly. Patients who suffer from these diseases have poor quality of life and shorter life span. The most common techniques for detection of these diseases are complete blood cell count, followed by electrophoresis and high performance liquid chromatography. In this connection, the results of this paper indicate the potential of a new technique, based on spectral analysis of blood plasma and cellular components, to detect SCD and Thai with accuracy of 90% and above. To the best of our knowledge this would be the first report on spectral pathology of hemoglobinopathy.

机译：镰状细胞病（SCD）和地中海贫血（Thal）是最常见的遗传性常染色体隐性血液病，可导致血管闭塞和脾肿大等并发症。患有这些疾病的患者的生活质量较差，寿命较短。检测这些疾病最常用的技术是完整的血细胞计数，然后进行电泳和高效液相色谱。在这方面，本文的结果表明了一种基于血浆和细胞成分的光谱分析的新技术的潜力，该技术可以检测SCD和Thai的准确性达到90％以上。据我们所知，这将是关于血红蛋白病的光谱病理学的首次报道。

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来源
《Photodiagnosis and Photodynamic Therapy》 |2013年第4期|429-433|共5页
作者
V. Masilamani; M.S. Al Salhi; S. Devanesan; Farjah H. AlGahtani; Khalid M. Abu-Salah; I. Ahamad; P. Agastian;
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作者单位

Department of Physics and Astronomy, King Saud University, KSA;

Department of Physics and Astronomy, King Saud University, KSA;

Research and Development Centre Bharathiar University, Coimbatore, India;

Department of Hematology, King Khalid University, KSA;

Kins Abdullah Institute for Nanotechnolosy, Kins Saud University, KSA;

Kins Abdullah Institute for Nanotechnolosy, Kins Saud University, KSA;

Department of Biotechnolosy, Loyola Collese Chennai, India;

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正文语种 eng
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关键词
Fluorescence spectra; Synchronous fluorescence; Sickle cell disease and thalassemia; Photo diagnosis;

机译：荧光光谱;同步荧光;镰状细胞病和地中海贫血;照片诊断;

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1. Corrigendum to 'Spectral detection of sickle cell anemia and thalassemia' [Photodiagn. Photodyn. Ther. 10 (2013) 429-433] [J] . Masilamani V., Al Salhi M. S., Devanesan S., Photodiagnosis and Photodynamic Therapy . 2019,第SEPa期

机译：“镰状细胞贫血和地中海贫血的频谱检测”勘误[Photodiagn。 Photodyn。那个10（2013）429-433]
2. Corrigendum to 'Spectral detection of sickle cell anemia and thalassemia' [Photodiagn. Photodyn. Ther. 10 (2013) 429-433] [J] . Masilamani V., Al Salhi M. S., Devanesan S., Photodiagnosis and Photodynamic Therapy . 2019,第Sepa期

机译：“镰状细胞贫血和地中海贫血的频谱检测”勘误[Photodiagn。
3. Effect of hydroxyurea in sickle cell anemia: a clinical trial in children and teenagers with severe sickle cell anemia and sickle cell beta-thalassemia. [J] . Koren A, Segal Kupershmit-D, Zalman L, Pediatric Hematology and Oncology . 1999,第3期

机译：羟基脲在镰状细胞性贫血中的作用：针对患有严重镰状细胞性贫血和镰状细胞β-地中海贫血的儿童和青少年的临床试验。
4. Relative Deformability of Red Blood Cells in Sickle Cell Trait and Sickle Cell Anemia by Trapping and Dragging [C] . Rance Solomon, James Cooper, Gabriel Welker, Medical laser applications and laser-tissue interactions VI . 2013

机译：诱捕和拖动镰状细胞性状和镰状细胞性贫血中红细胞的相对变形能力
5. Correction of mouse models of sickle cell disease and beta-thalassemia using stem cell and genetic-based therapy. [D] . Levasseur, Dana N. 2003

机译：使用干细胞和基于基因的疗法校正镰状细胞病和β地中海贫血的小鼠模型。
6. Side effects of hydroxyurea in patients with Thalassemia major and thalassemia intermedia and sickle cell anemia [O] . A Ghasemi, B Keikhaei, R Ghodsi 2014

机译：羟基尿素在重度地中海贫血和地中海贫血中度和镰状细胞性贫血患者中的副作用
7. The First Observation of Homozygous Hemoglobin S-Alpha Thalassemia Disease and Two Types of Sickle Cell Thalassemia Disease: (a) Sickle Cell-Alpha Thalassemia Disease, (b) Sickle Cell-Beta Thalassemia Disease [O] . MUZAFFER AKSOY 1963

机译：首次观察纯合血红蛋白S-α血症症和两种类型的镰状细胞症：（a）镰状细胞 - α血症症，（b）镰状细胞 - β血症症

Spectral detection of sickle cell anemia and thalassemia

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