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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Correlations between photoactivable porphyrins' fluorescence, erythema and the pain induced by PDT on normal skin using ALA-derivatives
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Correlations between photoactivable porphyrins' fluorescence, erythema and the pain induced by PDT on normal skin using ALA-derivatives

机译：使用ALA衍生物的光活化卟啉的荧光，红斑与PDT在正常皮肤上引起的疼痛之间的相关性

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Background: Photodynamic therapy (PDT) with precursors of photoactivable porphyrins is a well-established treatment modality for skin pathologies as well as hair removal. Pain is a major side effect thereof, and it affects the treatment compliance and acceptance. Methods: Five male subjects underwent a PDT procedure on normal skin, either with a diode laser (635 nm) or a lamp (405 nm), 3 or 6h after application of various precursors of photoactivable porphyrins (ALA 1M; Metvix~® 1M; ALA-DGME 1M; ALA-DGME 3.66M). Light doses ranged from 30 to 150J/cm~2 and irradiances were 100 or 180mW/cm~2. Fluorescence measurements were performed just before PDT, pain was quantified during PDT, and erythema was determined 24 h afterwards. Results: Because precursor ALA-DGME was very selective for the pilosebaceous apparatus vs. the epidermis, we solely carried out the PDTs using this precursor. In the absence of light, no pain was reported. An increase in pain was observed when increasing the irradiance. A correlation was observed between the follicular fluorescence and the maximal pain score during PDT. A correlation was observed between follicular fluorescence and skin erythema, and between pain score and skin erythema. Conclusions: With our well-controlled PDT parameters and homogenous subjects' conditions, we showed that pain could be reduced by reducing irradiance during PDT procedures. With the various correlations observed, we conclude that both pain and PaP fluorescence are useful tools to predict the post-PDT tissue effects (side effects and outcome). We suggest that A(6) nerve fibres would be the best candidate as first generators of PDT-induced pain.
机译：背景：具有光活化卟啉前体的光动力疗法（PDT）是一种公认​​的皮肤病理学和脱毛治疗方法。疼痛是其主要的副作用，它会影响治疗的依从性和可接受性。方法：五名男性受试者在分别使用光敏性卟啉的各种前体（ALA 1M；Metvix®1M； 3D； 3D； 3D；或5M）后，用二极管激光器（635 nm）或灯（405 nm）在正常皮肤上进行PDT程序。 ALA-DGME 1M； ALA-DGME 3.66M）。光剂量范围为30至150J / cm〜2，辐照度为100或180mW / cm〜2。在PDT之前进行荧光测量，在PDT期间定量疼痛，然后在24 h后确定红斑。结果：由于前体ALA-DGME对于皮脂腺器械相对于表皮具有很高的选择性，因此我们仅使用该前体进行了PDT。在没有光照的情况下，没有疼痛的报道。当增加辐照度时，观察到疼痛增加。在PDT期间，卵泡荧光和最大疼痛评分之间存在相关性。在卵泡荧光和皮肤红斑之间，以及在疼痛评分和皮肤红斑之间观察到相关性。结论：在我们良好控制的PDT参数和同质受试者的情况下，我们表明可以通过减少PDT程序中的辐照度来减轻疼痛。通过观察到的各种相关性，我们得出结论，疼痛和PaP荧光都是预测PDT后组织效应（副作用和预后）的有用工具。我们建议，A（6）神经纤维将是PDT诱发疼痛的第一产生者的最佳人选。

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