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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Phototoxicity of phenothiazinium dyes against methicillin-resistant Staphylococcus aureus and multi-drug resistant Escherichia coli
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Phototoxicity of phenothiazinium dyes against methicillin-resistant Staphylococcus aureus and multi-drug resistant Escherichia coli

机译：吩噻嗪鎓染料对耐甲氧西林的金黄色葡萄球菌和耐多种药物的大肠杆菌的光毒性

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Background: Photodynamic inactivation (PDI) has been investigated to cope with the increasing incidence of multidrug-resistant (MDR) pathogens. Here we studied the PDI mediated by methy- lene blue (MB) and toluidine blue 0 (TBO) in clinical methicillin-resistant Staphylococcus aureus and MDR Escherichia coli, together with their corresponding American Type Culture Collection (ATCC) strains. Methods: Effect of photosensitizer concentration (12.5,25,50 μg/ml) and laser irradiation time (10, 20 and 30 min) on lethal photosensitization was investigated. Results: TBO was more effective. TBO at 50 μg/ml, 46.8 J cm~(-2), exhibited 0.7 log killing for MDR E. coli and 1.7 log killing for E. coli (ATCC 25922); 3.1 log killing for MRSA, and 4.2 log killing for S. aureus (ATCC 25923). MB at 50 μg/ml, 163.8 J cm~(-2), only exhibited 2.2 log killing in MRSA and 3.1 log killing in S. aureus (ATCC 25923). MB (50μg/ml, 163.8Jcm~(-2)) induced 0.2 log killing for MDR E. coli and 0.3 log killing for E. coli (ATCC 25922). After TBO-PDI, MDR isolates were more susceptible to some antibiotics than control groups. Conclusion: Our studied clinical isolates were more resistant to PDI-mediated killing than their ATCC reference strains. Thus, TBO/MB-mediated PDI in other MDR isolates deserves further investigation.
机译：背景：已经研究了光动力灭活（PDI）以应对多重耐药性（MDR）病原体的发病率增加。在这里，我们研究了在耐甲氧西林的金黄色葡萄球菌和MDR大肠杆菌中，由甲乙蓝（MB）和甲苯胺蓝0（TBO）介导的PDI及其相应的美国典型培养物保藏中心（ATCC）菌株。方法：研究了光敏剂浓度（12.5、25、50μg/ ml）和激光照射时间（10、20和30分钟）对致死性光敏性的影响。结果：TBO更有效。 TBO为50μg/ ml，46.8 J cm〜（-2），对MDR E. coli杀灭0.7 log，对E. coli杀灭1.7 log（ATCC 25922）； MRSA的3.1日志杀死，金黄色葡萄球菌的4.2日志杀死（ATCC 25923）。 50μg/ ml，163.8 J cm〜（-2）的MB仅在MRSA中表现出2.2 log杀灭和在金黄色葡萄球菌中显示3.1 log杀灭（ATCC 25923）。 MB（50μg/ ml，163.8Jcm〜（-2））导致MDR大肠杆菌杀灭0.2 log和大肠杆菌（ATCC 25922）杀死0.3 log。 TBO-PDI后，MDR分离物比对照组更易受某些抗生素的影响。结论：我们研究的临床分离株比其ATCC参考菌株对PDI介导的杀伤力更有抵抗力。因此，其他MDR分离物中TBO / MB介导的PDI值得进一步研究。

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