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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Autofluorescence endoscopy with 'real-time' digital image processing in differential diagnostics of selected benign and malignant lesions in the oesophagus
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Autofluorescence endoscopy with 'real-time' digital image processing in differential diagnostics of selected benign and malignant lesions in the oesophagus

机译：带有“实时”数字图像处理功能的自发荧光内窥镜可对食道中的良性和恶性病变进行鉴别诊断

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摘要

Background: Oesophageal papilloma and Barrett's oesophagus are benign lesions known as risk factors of carcinoma in the oesophagus. Therefore, it is important to diagnose these early changes before neoplastic transformation. Method: Autofluorescence endoscopy is a fast and non-invasive method of imaging of tissues based on the natural fluorescence of endogenous fluorophores. The aim of this study was to prove the diagnostic utility of autofluorescence endoscopy with digital image processing in histological diagnosis of endoscopic findings in the upper digestive tract, primarily in the imaging of oesophageal papilloma. Results: During the retrospective analysis of about 200 endoscopic procedures in the upper digestive tract, 67 cases of benign, precancerous or cancerous changes were found. White light endoscopy (WLE) image, single-channel (red or green) autofluorescence images, as well as green and red fluorescence intensities in two modal fluorescence image and red-to-green (R/G) ratio (Numerical Colour Value, NCV) were correlated with histopathologic results. The NCV analysis in autofluorescence imaging (AFI) showed increased R/G ratio in cancerous changes in 96% vs. 85% in WLE. Simultaneous analysis with digital image processing allowed us to diagnose suspicious tissue as cancerous in all of cases. Barrett's metaplasia was confirmed in 90% vs. 79% (AFI vs. WLE), and 98% in imaging with digital image processing. In benign lesions, WLE allowed us to exclude tissue as malignant in 85%. Using autofluorescence endoscopy R/G ratio was increased in only 10% of benign changes causing the picture to be interpreted as suspicious, but when both methods were used together, 97.5% were cases excluded as malignancies. Mean R/G ratios were estimated to be 2.5 in cancers, 1.25 in Barrett's metaplasia and 0.75 in benign changes and were statistically significant (p = 0.04).rnConclusion: Autofluorescence imaging is a sensitive method to diagnose precancerous and cancerous early stages of the diseases located in oesophagus. Especially in two-modal imaging including white light endoscopy, autofluorescence imaging with digital image processing seems to be a useful modality of early diagnostics. Also in observation of papilloma changes, it facilitates differentiation between neoplastic and benign lesions and more accurate estimation of the risk of potential malignancy.
机译：背景：食道乳头状瘤和巴雷特食管是良性病变，被称为食管癌的危险因素。因此，重要的是在肿瘤转化之前诊断这些早期变化。方法：自发荧光内窥镜检查是一种基于内源性荧光团的自然荧光的快速，无创的​​组织成像方法。这项研究的目的是证明带有数字图像处理的自发荧光内窥镜在上消化道内窥镜检查的组织学诊断中的诊断实用性，主要是在食道乳头状瘤的成像中。结果：在对上消化道约200例内镜检查的回顾性分析中，发现67例良性，癌前或癌变。白光内窥镜（WLE）图像，单通道（红色或绿色）自发荧光图像以及两个模态荧光图像中的绿色和红色荧光强度以及红与绿（R / G）比率（数值色值，NCV） ）与组织病理学结果相关。自体荧光成像（AFI）中的NCV分析显示，癌变中R / G比率增加，分别为96％和WLE中的85％。通过数字图像处理的同时分析，使我们能够在所有情况下将可疑组织诊断为癌性。在使用数字图像处理的成像中，Barrett的化生率分别为90％和79％（AFI和WLE）和98％。在良性病变中，WLE允许我们排除85％的恶性组织。使用自发荧光内窥镜检查，良性变化中R / G比率仅增加了10％，导致图片被解释为可疑，但是当两种方法一起使用时，有97.5％的病例被排除为恶性肿瘤。癌症的平均R / G比估计为2.5，巴雷特化生的平均R / G比为1.25，良性改变的平均R / G比为0.75，具有统计学意义（p = 0.04）。结论：自体荧光成像是诊断癌症前期和癌前期疾病的灵敏方法。位于食道。特别是在包括白光内窥镜在内的两种模式成像中，具有数字图像处理功能的自发荧光成像似乎是早期诊断的一种有用方式。同样，在观察乳头状瘤的变化时，它有助于区分肿瘤性病变和良性病变，并更准确地估计潜在恶性肿瘤的风险。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2012年第1期|p.5-10|共6页
  • 作者

    Karolina Sieroh-Stottny; Sebastian Kwiatek; Wojciech Latos; Aleksandra Kawczyk-Krupka; Grzegorz Cieslar; Agata Stanek; Damian Ziaja; Andrzej M. Bugaj M.Pharm; Aleksander Sieron;

  • 作者单位

    Chair and Clinical Department of Internal Diseases, Angiology and Physical Medicine, Centre for Laser Diasnostics and Therapy, Silesian Medical University, Bytom, Poland;

    Chair and Clinical Department of Internal Diseases, Angiology and Physical Medicine, Centre for Laser Diasnostics and Therapy, Silesian Medical University, Bytom, Poland;

    Chair and Clinical Department of Internal Diseases, Angiology and Physical Medicine, Centre for Laser Diasnostics and Therapy, Silesian Medical University, Bytom, Poland;

    Chair and Clinical Department of Internal Diseases, Angiology and Physical Medicine, Centre for Laser Diasnostics and Therapy, Silesian Medical University, Bytom, Poland;

    Chair and Clinical Department of Internal Diseases, Angiology and Physical Medicine, Centre for Laser Diasnostics and Therapy, Silesian Medical University, Bytom, Poland;

    Chair and Clinical Department of Internal Diseases, Angiology and Physical Medicine, Centre for Laser Diasnostics and Therapy, Silesian Medical University, Bytom, Poland;

    Department of General and Vascular Surgery, Silesian Medical University, Katowice, Poland;

    Chair and Clinical Department of Internal Diseases, Angiology and Physical Medicine, Centre for Laser Diasnostics and Therapy, Silesian Medical University, Bytom, Poland;

    Chair and Clinical Department of Internal Diseases, Angiology and Physical Medicine, Centre for Laser Diasnostics and Therapy, Silesian Medical University, Bytom, Poland;

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  • 关键词

    autofluorescence; real-time imaging endoscopy; oesophagus; barrett's oesophagus; oesophageal papilloma; benign and malignant lesions; differential diagnostics;

    机译：自发荧光实时成像内窥镜检查;食管;巴雷特的食管;食道乳头状瘤良恶性病变;差异诊断;

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