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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Vascular targeted photodynamic therapy for bleeding gastrointestinal mucosal vascular lesions: A preliminary study
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Vascular targeted photodynamic therapy for bleeding gastrointestinal mucosal vascular lesions: A preliminary study

机译：血管靶向光动力疗法治疗消化道粘膜血管病变的初步研究

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摘要

Background: Vascular-targeted photodynamic therapy (V-PDT) has shown good selectivity and efficacy in the treatment of certain types of vascular disease, including port wine stains, age-related macular degeneration, and esophageal varices. This study was conducted to test the efficacy and safety of V-PDT in the treatment of gastrointestinal (Gl) bleeding caused by the abnormal dilatation of capillaries. Methods: Patients with bleeding Gl mucosal vascular lesions treated with V-PDT were included in this retrospective study. The efficiency of V-PDT was analyzed by comparing the documented endoscopy results, hemoglobin levels, and transfusion requirements before and at 6 months after the last V-PDT. Side effects during and after V-PDT and follow-up results were also analyzed. Results: Seven patients with bleeding Gl mucosal vascular lesions were treated with V-PDT. After 1-4 V-PDT sessions, all patients no longer needed transfusions to maintain a stable hemoglobin level during the follow-up period of 6 months. The mean hemoglobin level of the seven patients improved from 6.21 ± 1.48 g/dl to 11.66 ± 1.21 g/dl (p ＜ 0.001), and the Gl bleeding and melena of all the patients disappeared. No perforations, strictures, scars, or episodes of photosensiti-zation occurred in the seven patients, and there were no recurrences of Gl bleeding during the 1-21 months of further follow-up. Conclusions: This preliminary study indicated that V-PDT is a highly selective, safe, well-tolerated, and effective treatment modality for bleeding Gl mucosal vascular lesions. However, prospective studies with larger sample sizes are needed to confirm this finding.
机译：背景：针对血管的光动力疗法（V-PDT）在治疗某些类型的血管疾病（包括波特酒色斑，年龄相关性黄斑变性和食管静脉曲张）方面显示出良好的选择性和有效性。进行该研究以测试V-PDT在治疗由毛细血管异常扩张引起的胃肠道（G1）出血中的有效性和安全性。方法：这项回顾性研究纳入了接受V-PDT治疗的出血性G1粘膜血管病变患者。通过比较最后一次V-PDT之前和之后6个月的内窥镜检查结果，血红蛋白水平和输血需求，分析了V-PDT的效率。还分析了V-PDT期间和之后的副作用以及随访结果。结果：7例出血性G1粘膜血管病变患者接受了V-PDT治疗。 1-4次V-PDT疗程后，在6个月的随访期内，所有患者不再需要输血以维持稳定的血红蛋白水平。 7名患者的平均血红蛋白水平从6.21±1.48 g / dl提高到11.66±1.21 g / dl（p ＜0.001），所有患者的Gl出血和黑斑消失。在这7名患者中没有出现穿孔，狭窄，疤痕或光敏发作，并且在进一步随访的1-21个月内没有复发的G1出血。结论：这项初步研究表明，V-PDT是高度有效，安全，耐受性良好的G1黏膜血管病变出血治疗方法。但是，需要采用更大样本量的前瞻性研究来证实这一发现。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2012年第2期|109-117|共9页
  • 作者

    Haixia Qiu; Yongping Mao; Ying Gu; Ying Wang; Jianguo Zhu; Jing Zeng;

  • 作者单位

    Department of Laser Medicine, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China;

    Department of Gastroenterolosy and Hepatology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China;

    Department of Laser Medicine, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China;

    Department of Laser Medicine, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China;

    Department of Laser Medicine, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China;

    Department of Laser Medicine, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China;

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  • 正文语种 eng
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  • 关键词

    Gastrointestinal; Vascular lesions; Photodynamic therapy; Vascular-targeted;

    机译：胃肠道;血管病变;光动力疗法;血管靶向;

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