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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Combination of Fospeg-IPDT and a natural antioxidant compound prevents photosensitivity in a murine prostate cancer tumour model
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Combination of Fospeg-IPDT and a natural antioxidant compound prevents photosensitivity in a murine prostate cancer tumour model

机译：Fospeg-IPDT和天然抗氧化剂的组合可防止小鼠前列腺癌肿瘤模型中的光敏性

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摘要

Background: The aim of the present research was to investigate the potential use of a natural compound rich in antioxidant agents, derived from Pinus halepensis (P. halepensis), to prevent PDT induced photosensitivity. The present research progressed in two levels. The first one evolved the optimization of Fospeg-interstitial photodynamic therapy (IPDT) in a prostate cancer animal model. In the second one, P. halepensis bark extract, was evaluated for its potential use to prevent photosensitivity. Methods: Two sets of experiments were performed, IPDT only and IPDT in the presence of antioxidant. For both of them, Fospeg was administrated intravenously to SCID mice bearing prostate cancer, followed by IPDT after 6 h. For the IPDT + antioxidant experiments, P. halepensis was injected intratumourously 1 h prior the tumour illumination. Treatment outcome was monitored twice a week by an imaging system and by measuring tumour dimensions using a caliper. Photosensitivity was assessed by monitoring erythema of the tail using the imaging system. Results: IPDT with Fospeg and 15 J total light energy is a therapeutic scheme that can eliminate tumours in the murine model of prostate cancer. Two months after complete tumour remission no tumour recurrence was observed. Also, the cosmetic outcome of the research was excellent. The major drawback of this treatment scheme was that 90% of the animals developed photosensitivity. The addition of P. halepensis bark extract resulted in prevention of the photosensitivity, leaving PDT outcome unaffected. Conclusions: The combined use of PDT and the used antioxidant agent could broaden the implementation of photodynamic therapy, by eliminating photosensitivity.
机译：背景：本研究的目的是研究潜在的富含抗氧化剂的天然化合物的起源，该化合物源自哈尔滨松（P. halepensis），以防止PDT引起的光敏性。目前的研究分为两个层次。第一个在前列腺癌动物模型中发展了Fospeg间质光动力疗法（IPDT）的优化。在第二篇文章中，对哈氏疟原虫树皮提取物的潜在用途进行了评估，以预防光敏性。方法：进行了两组实验，仅IPDT和在抗氧化剂存在下的IPDT。对于这两种动物，将Fospeg静脉内给药于患有前列腺癌的SCID小鼠，然后在6小时后进行IPDT。对于IPDT +抗氧化剂实验，在肿瘤照射前1小时在肿瘤内注射halepensis。每周两次通过成像系统和使用卡尺测量肿瘤尺寸来监测治疗结果。通过使用成像系统监测尾部红斑来评估光敏性。结果：具有Fospeg和15 J总光能的IPDT是一种可以消除前列腺癌小鼠模型中的肿瘤的治疗方案。完全缓解肿瘤后两个月，未观察到肿瘤复发。另外，该研究的美容效果极好。这种治疗方案的主要缺点是90％的动物发展了光敏性。 P. halepensis树皮提取物的添加导致防止了光敏性，而使PDT结果不受影响。结论：PDT和抗氧化剂的联合使用可以消除光敏性，从而扩大光动力疗法的实施范围。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2012年第2期|100-108|共9页
  • 作者

    Aspasia Petri; Eleni Alexandratou; Maria Kyriazi; Michail Rallis; Vassilios Roussis; Dido Yova;

  • 作者单位

    Laboratory of Biomedical Optics and Applied Biophysics, School of Electrical and Computer Engineering, National Technical University of Athens, Iroon Politechniou 9, Zografou Campus, 15780 Athens, Greece;

    Laboratory of Biomedical Optics and Applied Biophysics, School of Electrical and Computer Engineering, National Technical University of Athens, Iroon Politechniou 9, Zografou Campus, 15780 Athens, Greece;

    Laboratory of Biomedical Optics and Applied Biophysics, School of Electrical and Computer Engineering, National Technical University of Athens, Iroon Politechniou 9, Zografou Campus, 15780 Athens, Greece;

    Division of Pharmaceutical Technology, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli, Zografou Campus, 15771 Athens, Greece;

    Division of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupoli, Zografou Campus, 15771 Athens, Greece;

    Laboratory of Biomedical Optics and Applied Biophysics, School of Electrical and Computer Engineering, National Technical University of Athens, Iroon Politechniou 9, Zografou Campus, 15780 Athens, Greece;

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  • 正文语种 eng
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  • 关键词

    Fospeg; Antioxidants; Photosensitivity; IPDT; Pinus halepensis;

    机译：福斯佩格;抗氧化剂;光敏性IPDT;哈尔滨松;

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