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Reply to 'Championing photoantimicrobial discovery'

机译：回复“冠军光抗菌素发现”

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摘要

Mark Wainwright's reply (ref) to the letter written by Hamblin and Dai [1] makes some interesting and rele-vant points relating to the choice of a photosensitizer for potential clinical trials of photodynamic therapy (PDT) for surgical site infections. Dr Wainwright discusses the rela-tive merits and disadvantages of different members of the phenothiazinium dye family related to the parent compound methylene blue (MB). He agrees that the compounds with increased methylation on the basic molecular framework of the phenothiazinium dye such as new methylene blue (NAAB), methyl methylene blue (MMB) and dimethylmethy-lene blue (DAAMB) are more powerful photosensitizing agents against both bacteria (and other microorganisms) as well as mammalian cells. However he then asserts that these derivatives have "high and rapid dark cytotoxicity" towards mammalian cells as reported in his paper in 1997 [2].
机译：马克·温赖特（Mark Wainwright）对Hamblin和Dai [1]所写信的答复（参考）提出了一些有趣的和相对的观点，这些观点涉及为手术部位感染的光动力疗法（PDT）的潜在临床试验选择光敏剂。 Wainwright博士讨论了与母体化合物亚甲蓝（MB）有关的吩噻嗪鎓染料家族不同成员的相对优缺点。他同意，在吩噻嗪鎓染料的基本分子框架上甲基化增强的化合物，例如新的亚甲基蓝（NAAB），甲基亚甲基蓝（MMB）和二甲基甲基兰蓝（DAAMB）是对两种细菌（和其他微生物）以及哺乳动物细胞。然而，他随后断言，如他在1997年的论文中报道的那样，这些衍生物对哺乳动物细胞具有“高而快速的暗细胞毒性” [2]。

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    《Photodiagnosis and Photodynamic Therapy》 |2011年第3期|p.289-290|共2页
  • 作者

    Michael R. Hamblin;

  • 作者单位

    Wellman Center for Photomedicine, MassachusettsGeneral Hospital, Boston, MA, United States Department of Dermatology, Harvard Medical School,Boston, MA, United States Harvard-MIT Division of Health Sciences and Technology,Cambridse, MA, United States Wellman Center for Photomedicine, Massachusetts General Hospital, Boston,MA, United States.;

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