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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Bioimpedance for pain monitoring during cutaneous photodynamic therapy: Preliminary study
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Bioimpedance for pain monitoring during cutaneous photodynamic therapy: Preliminary study

机译：皮肤光动力疗法过程中用于监测疼痛的生物阻抗：初步研究

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摘要

Background: Pain is a well-known problem associated with light exposure during topical photodynamic therapy (PDT). Different methods for dealing with the pain have been developed over the past years, ranging from cooling with air or water to nerve blocking. However, the mechanisms responsible for the pain induction have not yet been fully understood. Aim: This study aims to evaluate bioimpedance in situ measurements of human skin as a method to shed light on pain-inducing real-time changes during light exposure during topical PDT. Methods: Cream containing 20% aminolevulinic acid (ALA) was applied on forearms of ten healthy human volunteers. After 24 h incubation, the cream was removed and the spots were exposed to red laser light (636nm, 300mW/cm~2). During light exposure bioimpedance measurements with a 4-electrode set-up were taken at two frequencies (10Hz and 100kHz). Results: A significant drop in skin impedance at high and low frequencies coincided with onset of pain during light exposure of spots treated with ALA. A similar drop was not observed for controls.Conclusions: Bioimpedance spectroscopy can provide valuable data for real-time observation of changes in skin, and may contribute to an increased understanding of the mechanisms responsible for induction of pain during topical PDT. Future studies are needed.
机译：背景：疼痛是与局部光动力疗法（PDT）期间的曝光有关的众所周知的问题。过去几年中，已经开发出各种方法来治疗疼痛，从用空气或水冷却到神经阻滞不等。但是，引起疼痛的机制尚未完全了解。目的：本研究旨在评估人体皮肤的生物阻抗原位测量方法，以揭示局部PDT曝光期间疼痛引起的实时变化。方法：将含有20％氨基乙酰丙酸（ALA）的乳膏涂在10名健康人类志愿者的前臂上。温育24小时后，除去乳膏，并将斑点暴露于红色激光（636nm，300mW / cm〜2）。在曝光期间，在两个频率（10Hz和100kHz）下采用4电极设置进行生物阻抗测量。结果：在高频和低频下皮肤阻抗的显着下降与在用ALA治疗的斑点曝光期间的疼痛发作同时发生。结论：生物阻抗谱可以为实时观察皮肤变化提供有价值的数据，并且可能有助于增进对局部PDT过程中引起疼痛的机制的了解。需要进一步的研究。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2011年第4期|p.307-313|共7页
  • 作者

    Patrycja Mikolajewska MSc; Ola Taarud Romoen; Orjan G. Martinsen; Vladimir lani; Johan Moan; Sverre Grimnes; Asta Juzeniene;

  • 作者单位

    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway;

    Department of Physics, University of Oslo, Blindern, 0316 Oslo, Norway;

    Department of Physics, University of Oslo, Blindern, 0316 Oslo, Norway Department of Clinical and Biomedical Engineering, Oslo University Hospital, Oslo, Norway;

    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway;

    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway Department of Physics, University of Oslo, Blindern, 0316 Oslo, Norway;

    Department of Physics, University of Oslo, Blindern, 0316 Oslo, Norway Department of Clinical and Biomedical Engineering, Oslo University Hospital, Oslo, Norway;

    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway;

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  • 正文语种 eng
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  • 关键词

    topical photodynamic therapy (PDT); bioimpedance spectroscopy; fluorescence spectroscopy; protoporphyrin IX (PpLX); aminolevulinic acid (ALA); pain;

    机译：局部光动力疗法（PDT）;生物阻抗谱;荧光光谱原卟啉IX（PpLX）;氨基乙酰丙酸（ALA）;痛;

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