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首页> 外文期刊>Photodiagnosis and photodynamics therapy >Taking treatment decisions in non-melanoma skin cancer-The place for topical photodynamic therapy (PDT)
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Taking treatment decisions in non-melanoma skin cancer-The place for topical photodynamic therapy (PDT)

机译：在非黑素瘤皮肤癌中做出治疗决策-局部光动力疗法（PDT）的地方

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Background: Epithelial non-melanoma skin cancer (NMSC) like actinic keratosis (AK), Bowen's disease (BD) and basal cell carcinoma (BCC) represent the most common malignancies in the fair skinned population. Epidemiological data reveal high incidences, especially for actinic ker-atoses, which are basically non-invasive squamous cell carcinomas, but fortunately bear a low risk of mortality for a single lesion. Nevertheless these lesions should be generally treated if other factors such as the state of the patient indicate that this is appropriate. The appearance of new treatment modalities like immuno-modulating topical agents, topical diclofenac, and photodynamic therapy in addition to a long list of already established treatments (curettage, surgery, cryotherapy, topical 5-fluorouracil, and many others) have led to the fact that patients and treating physicians have a large spectrum of therapeutic options to choose from. The same - with some variations - holds true forBowen's disease and BCC.rnMethods: Aim of this article is to offer an overview over NMSCs and their treatment options with emphasis on photodynamic therapy (PDT) as classical indications for PDT, to provide resources for guidelines for the treatment of these diseases, and to position PDT in this context by helping selecting patients that would profit most from topical PDT.rnResults: Sufficient evidence is available to regard PDT as a standard treatment modality for NMSC. In addition to randomized controlled trials, long-term experience helps to find out the most appropriate treatment modality in a given patient.rnConclusion: Physicians treating NMSC should have access to PDT and be trained and experienced in its use.
机译：背景：上皮非黑素瘤皮肤癌（NMSC），如光化性角化病（AK），鲍恩氏病（BD）和基底细胞癌（BCC），是白皙人群中最常见的恶性肿瘤。流行病学数据显示，尤其是光化性角膜癌的发病率高，这基本上是非侵入性鳞状细胞癌，但幸运的是，单个病变的死亡风险较低。但是，如果其他因素（例如患者的状况）表明这是适当的，则通常应该对这些病变进行治疗。除了已经建立的一长串治疗方法（刮宫，手术，冷冻疗法，局部5-氟尿嘧啶和许多其他方法）外，新的治疗方式如免疫调节性局部用药，局部双氯芬酸和光动力疗法的出现也导致了这一事实。患者和主治医师有多种治疗选择可供选择。方法：本文的目的是概述NMSC及其治疗方案，重点是光动力疗法（PDT）作为PDT的经典指征，为指南提供资源结果：有足够的证据将PDT视为NMSC的标准治疗方法。除了随机对照试验外，长期经验还有助于找出特定患者的最合适治疗方式。结论：治疗NMSC的医师应能使用PDT，并应接受有关PDT的培训和经验培训。

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