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首页> 外文期刊>Photodiagnosis and photodynamics therapy >Demonstration of protoporphyrin IX (PpIX) localized to areas of palmar skin injected with 5-aminolevulinic acid (ALA) and pre-treated with a fractionated CO_2 laser prior to topically applied ALA
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Demonstration of protoporphyrin IX (PpIX) localized to areas of palmar skin injected with 5-aminolevulinic acid (ALA) and pre-treated with a fractionated CO_2 laser prior to topically applied ALA

机译：演示原卟啉IX（PpIX）定位于注射有5-氨基乙酰丙酸（ALA）并在局部应用ALA之前用分馏CO_2激光预处理的手掌皮肤区域

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Background: Several techniques designed to enhance ALA delivery into subcorneal layers of palmar skin are described.rnMethods: Six palms from three subjects were treated with topical ALA, iontophoresis enhanced delivery of ALA, intradermal injections of ALA solution, or fractionated CO_2 laser (with or without erbium:YAG surface ablation). The relative efficacy of each technique was determined using Wood's lamp illumination for the presence of fluorescent PplX.rnResults: Palms treated with topically applied ALA alone or with iontophoresis pre-treatment failed to exhibit fluorescence. The palm treated with intradermal injections of ALA and the palms pre-treated with fractionated CO_2 laser with or without erbium:YAG laser surface ablation exhibited fluorescence at treatment areas.rnConclusion: Both intradermal injections and fractionated CO_2 laser (with or without erbium:YAG laser pre-treatment) may provide an effective means for delivery of ALA into subcorneal layers of palmar skin. Numerous potential clinical applications of these techniques (including treatment of localized palmar hyperhidrosis) exist.
机译：背景：描述了几种旨在增强ALA输送至手掌皮肤角膜下层的技术。方法：对三名受试者的六只手掌进行局部ALA处理，离子电渗疗法增强ALA输送，皮内注射ALA溶液或分次CO_2激光（用或不含：YAG表面消融）。结果：用单独局部施用的ALA或离子电渗疗法预处理的手掌未显示荧光，使用伍德氏灯照明确定每种技术的相对功效。经皮内注射ALA处理的手掌和经分装CO_2激光预处理或有无without：YAG激光表面消融的手掌在治疗部位均显示荧光。rn结论：皮内注射和分装CO_2激光（有或没有without：YAG激光）预处理）可为将ALA输送到手掌皮肤的角膜下层提供有效手段。这些技术有许多潜在的临床应用（包括治疗手掌多汗症）。

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