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Targeted laryngeal photodynamic therapy with a balloon diffusing light source

机译:球囊扩散光源的定向喉光动力疗法

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Photodynamic therapy (PDT) has been used for pre-malignant mucosal lesions. In an attempt to treat a patient with recurrent high-grade dysplasia of the glottic larynx, we were faced with technical challenges leading us to abandon the classic microlens fiber for a 2-cm long translucent diffusing balloon catheter to deliver photoactivating light to the targeted lesion. Real-time measurements confirmed stable photobleaching with augmentation of the prescribed light fluence secondary to light scatter in regions not in contact with the balloon diffuser. We report a potential new application of the balloon catheter that may be more suitable for anterior glottic lesions associated with minimal acute toxicity.
机译:光动力疗法(PDT)已用于恶性粘膜前病变。为了治疗患有声门喉复发性高度不典型增生的患者,我们面临着技术挑战,导致我们放弃了经典的微透镜光纤,而是将其用于2 cm长的半透明扩散球囊导管,以将光活化光传递至目标病变。实时测量结果证实了稳定的光漂白,并且在不与球囊扩散器接触的区域中,光散射继而增加了规定的光通量。我们报告了潜在的气球导管的新应用,它可能更适合与最小急性毒性相关的声门前病变。

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