• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Microneedle-mediated intradermal nanoparticle delivery: Potential for enhanced local administration of hydrophobic pre-formed photosensitisers
【24h】

Microneedle-mediated intradermal nanoparticle delivery: Potential for enhanced local administration of hydrophobic pre-formed photosensitisers

机译：微针介导的皮内纳米颗粒递送：增强疏水性预制光敏剂局部给药的潜力

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: To date, 5-aminolevulinic acid (ALA) has been the most widely used agent in topical photodynamic therapy (PDT). However, owing to the poor penetration of ALA into skin, ALA-PDT is inappropriate for difficult-to-treat deep skin neoplasias, such as nodular basal cell carcinoma. An alternative strategy to ALA-PDT is to use pre-formed photosensitisers, which can be activated at longer wavelengths, facilitating enhanced light penetration into skin. Owing to their relatively high molecular weights and often high lipophilicities, these compounds cannot be effectively administered topically. This study aimed to deliver a model hydrophobic dye, Nile red, into the skin using novel microneedle (MN) technology. Materials and methods: Nile red was incorporated into poly-lactide-co-glycolic acid (PLGA) nanoparticles using an emulsion and salting-out process. Polymeric MN arrays were prepared from aqueous blends of the mucoadhesive copolymer Gantrez~? AN-139 and tailored to contain 1.0 mg of Nile red-loaded PLGA nanoparticles. Intradermal delivery of Nile red was determined in vitro. Results: Uniform 150nm diameter PLGA nanoparticles were prepared containing 3.87 μg Nile red / mg of PLGA. Tissue penetration studies using excised porcine skin revealed that high tissue concentrations of Nile red were observed at 1.125 mm (382.63 ngcm~(-3)) following MN delivery. Conclusion: For the first time, polymeric microneedles (MN) have been employed to deliver a model lipophilic dye, Nile red, into excised porcine skin. Importantly, this is a one-step delivery strategy for the local delivery of highly hydrophobic agents, which overcomes many of the disadvantages of current delivery strategies.
机译：简介：迄今为止，5-氨基乙酰丙酸（ALA）已成为局部光动力疗法（PDT）中使用最广泛的药物。然而，由于ALA对皮肤的渗透性差，ALA-PDT不适用于难以治疗的深部皮肤肿瘤，例如结节性基底细胞癌。 ALA-PDT的替代策略是使用预先形成的光敏剂，该光敏剂可以在更长的波长下被激活，从而促进光透入皮肤。由于它们相对较高的分子量和通常较高的亲脂性，因此这些化合物不能有效地局部给药。这项研究旨在使用新型微针（MN）技术将模型疏水性染料尼罗红传递到皮肤中。材料和方法：使用乳液和盐析工艺将尼罗红掺入聚丙交酯-共-乙醇酸（PLGA）纳米颗粒中。由粘膜粘附共聚物Gantrez®的水性共混物制备聚合物MN阵列。 AN-139量身定制，可容纳1.0毫克的尼罗河红负载PLGA纳米粒子。体外测定尼罗红的皮内递送。结果：制备了均匀的150nm直径的PLGA纳米颗粒，其中包含3.87μg尼罗红/ mg PLGA。使用切除的猪皮进行的组织穿透研究表明，MN释放后在1.125 mm（382.63 ngcm〜（-3））处观察到高浓度的尼罗红。结论：第一次，聚合物微针（MN）已被用于将模型的亲脂性染料尼罗红传递到切除的猪皮肤中。重要的是，这是用于高度疏水性试剂的局部递送的一步式递送策略，其克服了当前递送策略的许多缺点。

著录项

  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2010年第4期|p.222-231|共10页
  • 作者

    Ryan F. Donnelly; Desmond I.J. Morrow; Francois Fay; Christopher J. Scott; Sharif Abdelghany; Raghu Raj Thakur Singh; Martin J. Garland; A. David Woolfson;

  • 作者单位

    School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK;

    School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK;

    School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK;

    School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK;

    School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK;

    School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK;

    School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK;

    School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    microneedles; nanoparticles; pre-formed photosensitisers; topical drug delivery;

    机译：微针纳米粒子预成型的光敏剂;局部用药;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号