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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Salvage photodynamic therapy for persistent oesophageal cancer after chemo/radiation therapy
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Salvage photodynamic therapy for persistent oesophageal cancer after chemo/radiation therapy

机译：化疗/放疗后持续性食管癌抢救光动力疗法

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Although oesophagectomy has been regarded as the standard treatment for oesophageal cancer, over 50% of patients are inoperable at presentation and 60-70% of cases have locally advanced tumour at diagnosis. Of the patients who undergo successful complete resection the majority succumb to local recurrence or metastatic disease, therefore, pre-operative chemotherapy (neo-adjuvant therapy) and chemo/radiotherapy (CRT) have been promoted for oesophageal cancer patients destined to be treated by surgical resection. General and local pathological tumour response, as well as the patients' tolerance to chemotherapy, are subject to variations. These influence both the post-chemotherapy operability rate and outcome. The idea of the endoscopic use of photodynamic therapy (PDT) in patients with local recurrence for residual endoluminal oesophageal cancer following neo-adjuvant chemotherapy or CRT, who cannot or will not have surgical resection is basically sound and is oncologically attractive. It is based on the premise that chemotherapy will affect the micro-metastatic lesions and that PDT will dispose of the tumour recurrence, or its residue, locally.
机译：尽管食道切除术已被认为是食道癌的标准治疗方法，但超过50％的患者在就诊时无法手术，而60-70％的患者在诊断时出现局部晚期肿瘤。因此，在成功完成彻底切除的患者中，大多数人会屈服于局部复发或转移性疾病，因此，对于注定要通过手术治疗的食道癌患者，术前化学疗法（新辅助疗法）和化学/放射疗法（CRT）已得到推广。切除。总体和局部病理性肿瘤反应以及患者对化疗的耐受性会有所不同。这些都影响化疗后的可手术率和结果。对于不能或不会进行手术切除的新辅助化疗或CRT后残留残余腔内食管癌局部复发的患者，内镜使用光动力疗法（PDT）的想法基本上是合理的，并且在肿瘤学上具有吸引力。这是基于这样的前提，即化学疗法将影响微转移病灶，PDT将局部处置肿瘤复发或其残留物。

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