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Bare fiber photodynamic therapy using porfimer sodium for esophageal disease

机译：porfimer钠治疗食管疾病的裸纤维光动力疗法

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During Digestive Disease Week 2005 in Chicago, Illinois, our group of 10 gastrointestinal photodynamic therapists met to discuss variations in procedural technique and treatment protocols. An extensive review of the use of photodynamic therapy (PDT) for esophageal disease has recently been published elsewhere [Wolf-sen HC. Present status of photodynamic therapy for high-grade dysplasia in Barrett's esophagus. J Clin Gastroenterol 2005;39(3):189-202]. This report, based mostly on clinical experience and common sense rather than evidence-based medicine, is a detailed discussion of pragmatic issues. In summary, our centers treat patients with Barrett's dysplasia, Barrett's or squamous cell carcinoma using the photosensitizer porfimer sodium (2 mg/kg total body weight) and bare fiber PDT (no fiber centering devices). Aggressive suppression of gastric acid is uniformly emphasized. The most common technique variables were the light energy source, light dosimetry and the amount of Barrett's mucosa treated during a course of PDT. Standardization of porfimer sodium PDT procedures and light dosimetry may enhance treatment outcomes.
机译：在伊利诺伊州芝加哥市的2005年消化系统疾病周期间，我们的10位胃肠道光动力治疗师小组举行了会议，讨论程序技术和治疗方案的变化。最近在其他地方发表了对光动力疗法（PDT）用于食道疾病的广泛综述[Wolf-sen HC。光动力疗法治疗巴雷特食管严重不典型增生的现状。 J Castro Gastroenterol 2005; 39（3）：189-202]。该报告主要基于临床经验和常识而不是循证医学，是对实用问题的详细讨论。总之，我们的中心使用光敏剂porfimer钠（总重2 mg / kg）和裸露的PDT（无纤维定心装置）治疗Barrett发育不良，Barrett或鳞状细胞癌患者。统一强调积极抑制胃酸。在PDT过程中，最常见的技术变量是光能源，光剂量和巴雷特粘膜的治疗量。 porfimer钠PDT程序和光剂量测定的标准化可增强治疗效果。

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