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首页> 外文期刊>Photodiagnosis and photodynamics therapy >Photodynamic therapy and endoscopic mucosal resection as minimally invasive approaches for the treatment of early esophageal tumors: Pre-clinical and clinical experience in Lausanne
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Photodynamic therapy and endoscopic mucosal resection as minimally invasive approaches for the treatment of early esophageal tumors: Pre-clinical and clinical experience in Lausanne

机译：光动力疗法和内镜黏膜切除术作为微创方法治疗早期食道肿瘤：洛桑的临床前和临床经验

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摘要

Esophageal cancer, when detected at an early stage, has a very good probability of being eradicated by surgery or radiotherapy. However, less aggressive treatments also tend to provide high rates of cure without the side effects of radical surgery or radiotherapy. Among them, photodynamic therapy and endoscopic mucosal resection have been experienced as alternative techniques for mucosal ablation in patients with superficial squamous-cell carcinoma (SCC) of the esophagus, or high-grade dysplasia and early stage adenocarcinoma arising in Barrett's esophagus. We report on the results of our clinical experience with photodynamic therapy and discuss about its advantages and limitations. We also present a pre-clinical study, which had evaluated the feasibility, efficacy, and safety of a promising new method of endoscopic mucosal resection (EMR) based on the use of a modified rigid esophagoscope. The animal model chosen was the sheep because of its similarities with humans regarding the thickness and histologic structure of the esophagus. This new resection modality offers a promising approach in comparison with other options currently available, namely EMRs performed with flexible gastroscopes. It appears to be superior in terms of the size of the resected specimen, the precision and regularity of the resection depth, and the accuracy of histological diagnosis with safety margins.
机译：食管癌在早期发现时，极有可能通过手术或放射疗法根除。但是，较不积极的治疗也往往会提供高治愈率，而没有根治性手术或放射疗法的副作用。其中，光动力疗法和内窥镜黏膜切除术已成为食管浅层鳞状细胞癌（SCC）或巴雷特食管发生的高度不典型增生和早期腺癌患者的黏膜消融替代技术。我们报告我们在光动力疗法方面的临床经验，并讨论其优点和局限性。我们还提出了一项临床前研究，该研究基于改良的刚性食管镜，评估了一种有前途的内窥镜黏膜切除术（EMR）新方法的可行性，有效性和安全性。选择的动物模型是绵羊，因为它在食管的厚度和组织学结构方面与人类相似。与当前可用的其他选项（即使用柔性胃镜执行的EMR）相比，这种新的切除方法提供了一种有前途的方法。就切除标本的大小，切除深度的准确性和规律性以及具有安全裕度的组织学诊断的准确性而言，它似乎是优越的。

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