Lipophilic cationic porphyrins as photodynamic sensitisers — Synthesis and structure-activity relationships

Robert Hudson; Huguette Savoie; Ross W. Boyle

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Lipophilic cationic porphyrins as photodynamic sensitisers — Synthesis and structure-activity relationships

机译：亲脂性阳离子卟啉作为光动力敏化剂—合成与构效关系

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摘要

A convenient synthesis of a range of phosphorous and nitrogen centred lipophilic cationic porphyrins is described. In vitro assays for photodynamic activity against human colorectal adenocarcinoma cells (HT-29) reveal significant differences based on substituents around the cation centres.

机译：描述了方便的一系列磷和氮中心的亲脂性阳离子卟啉的合成。针对人结肠直肠腺癌细胞（HT-29）的光动力学活性的体外测定表明，基于阳离子中心周围的取代基存在显着差异。

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来源
《Photodiagnosis and Photodynamic Therapy》 |2005年第3期|p.193-196|共4页
作者
Robert Hudson; Huguette Savoie; Ross W. Boyle;
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作者单位

Department of Chemistry, University of Hull, Kingston-upon-Hull, East Yorkshire HU6 7RX, UK;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
photodynamic therapy; cationic porphyrins; structure-activity relationships;

机译：光动力疗法;阳离子卟啉;构效关系;

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Lipophilic cationic porphyrins as photodynamic sensitisers — Synthesis and structure-activity relationships

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