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Photodynamic therapy (PDT) for lung cancer: the Yorkshire Laser Centre experience

机译：肺癌的光动力疗法（PDT）：约克郡激光中心的经验

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Background: The Yorkshire Laser Centre team have been engaged in photodynamic therapy (PDT) since 1990. In this article we review our experience in bronchoscopic PDT for lung cancer and outline our current indications and results. Methods: 160 patients in 2 groups entered into a prospective study: Group A (N = 144) were symptomatic with advanced inoperable disease and with presence of > 50% bronchial obstruction. Group E (N = 16) with early stage cancer and presence of superficial lesion confined to bronchial tree. All patients had standard investigation and work-up bronchoscopy and biopsy confirmation of cancer by cyto-histology. PDT method was intravenous administration of 2 mg/kg BW of Photofrin (Porfimer Sodium) followed by bronchoscopic illumination of 630 nm laser light. Results: There was no treatment-related mortality. Nine patients (5.6%) presented with skin photosensitivity reaction and another eight with respiratory complication. Group A: Symptom relief was achieved in all. This was matched by significant improvement in bronchial opening (58.1%). Survival was 9.6 months (mean) and 5 months (median), respectively. This was greater in patients with better performance status and lower stage of disease. Group E: Every patient had a complete response to treatment, some after two treatments. Survival in this group was 75.4 months (mean) and 69 months (median). Conclusions: Bronchoscopic PDT is indicated in both advanced and early stage lung cancer. In the former it provides symptomatic relief in all and survival benefit in some; in the latter it achieves long survival and potential cure.
机译：背景：约克郡激光中心团队自1990年以来一直从事光动力疗法（PDT）。在本文中，我们回顾了在支气管镜PDT治疗肺癌中的经验，并概述了当前的适应症和结果。方法：2组中的160例患者进行了一项前瞻性研究：A组（N = 144）伴有无法手术的晚期疾病，且支气管阻塞> 50％。 E组（N = 16），具有早期癌症和浅表性病变，局限于支气管树。所有患者均进行了标准的检查和支气管镜检查，并通过细胞组织学检查证实了癌症。 PDT方法是静脉注射2 mg / kg BW的Photofrin（Porfimer钠），然后通过支气管镜照射630 nm激光。结果：没有与治疗有关的死亡率。 9例（5.6％）出现皮肤光敏反应，另外8例出现呼吸系统并发症。 A组：全部缓解了症状。与此相伴的是，支气管开放明显改善（58.1％）。生存期分别为9.6个月（平均）和5个月（中位数）。表现状态较好且病程较低的患者中这一比例更高。 E组：每位患者对治疗都有完全的反应，有些经过两次治疗。该组的生存期分别为75.4个月（平均）和69个月（中位数）。结论：支气管镜PDT在晚期和早期肺癌中均适用。在前一种情况下，它可以为所有患者提供症状缓解，而在某些情况下可以为患者带来生存益处。在后者中，它可以实现长期生存和潜在的治愈。

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