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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Personal experience and observations on photodynamic therapy (PDT) for columnar epithelial lined (Barrett's) oesophagus and its neoplastic evolution
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Personal experience and observations on photodynamic therapy (PDT) for columnar epithelial lined (Barrett's) oesophagus and its neoplastic evolution

机译：柱状上皮内衬食管（Barrett）食管的光动力疗法（PDT）的个人经验和观察及其肿瘤演变

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摘要

The current generally accepted definition of Barrett's oesophagus (synonym columnar epithelial lined oesophagus: CELO) is a condition in which the mucosal coat of the lower oesophagus, for at least 3 cm above the gastro-oesophageal junction (GOJ) is lined by columnar epithelium instead of the usual squamous cell. The columnar mucosa can be of intestinal, fundic or cardiac variety. Norman Barrett, a British thoracic surgeon first observed this anomaly and referred to it in an article published in 1950 entitled "Chronic Peptic Ulcer of the Oesophagus and Oesophagitis". At the time Barrett called the condition congenital short oesophagus, believing that it was derived from a developmental anomaly in which part of the stomach with its gastric type mucosa but in tubular form, and in continuation with the oesophagus, remained in the mediastinum. Subsequent studies, notably by Allison and Johnston, indicated that Barrett's intra thoracic tubular stomach (short oesophagus) was in fact an "oesophagus lined with gastric mucous membrane". By 1957 Barrett altered his original views and adopted Allison and Johnton's suggestion. This culminated in the publication of another article "The Lower Oesophagus lined by Columnar Epithelium" where he laid down the criteria of the condition, which now bears his name. He emphasised that, despite mucosal anomaly of the lower oesophagus, the anatomical features of the hiatus and the peritoneal arrangement at the oesophago-gastric junction were normal. He also continued to believe that the columnar mucosa of the lower oesophagus was congenital in origin.
机译：目前普遍接受的Barrett食管定义（同义词：柱状上皮衬里食道：CELO）是一种条件，其中下食管的粘膜被覆在胃食管交界处（GOJ）至少3 cm处，而是用柱状上皮衬里通常的鳞状细胞。柱状粘膜可以是肠，胃或心脏的。英国胸外科医生诺曼·巴雷特（Norman Barrett）首次观察到这种异常现象，并在1950年发表的一篇题​​为“食管和食道炎的慢性消化性溃疡”的文章中对此进行了提及。当时Barrett称这种情况为先天性短食道，是因为它起源于发育异常，在该异常中，部分胃部具有胃粘膜但呈管状，并与食道连续，并保留在纵隔中。随后的研究，特别是艾莉森（Allison）和约翰斯顿（Johnston）的研究表明，巴雷特的胸腔内管状胃（短食道）实际上是“衬有胃粘膜的食道”。到1957年，巴雷特改变了他最初的观点，并采纳了艾莉森和约翰顿的建议。这在另一篇文章“由柱状上皮衬砌的下层食管”的发表中达到了高潮，在那里他提出了条件的标准，现在以他的名字命名。他强调，尽管下食管粘膜异常，但食管-胃交界处的裂孔和腹膜排列是正常的。他还继续认为下食管的柱状粘膜起源于先天性。

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