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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Low-cost light-induced therapy to treat rickettsial infection
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Low-cost light-induced therapy to treat rickettsial infection

机译：低成本的光诱导疗法来治疗立克次体感染

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Antimicrobial photodynamic therapy uses a nontoxic photosensitizer with the assistance of harmless visible light to activate the photosensitizer. Consequently, the excited state of the photosensitizer interacts with molecular oxygen to produce reactive oxygen species, which have the antimicrobial effect. In this study, we evaluated the effect of photodynamic therapy on Vero cells infected with rickettsia using methylene blue as a photosensitizer along with red light. A significant reduction (by 96%) in the number of viable Rickettsia slovaca was determined by quantitative RT-PCR 48 h after the treatment with methylene blue followed by 30 min of red light excitation. A statistically significant reduction of R. slovaca was also recorded with pretreatment (by 99%). To the best of our knowledge, this result is the first one in the literature to confirm the effectiveness of photodynamic therapy for the elimination of R. slovaca and to suggest this technique as a good supportive treatment for rickettsial infections.
机译：抗菌光动力疗法在无害可见光的辅助下使用无毒的光敏剂来激活光敏剂。因此，光敏剂的激发态与分子氧相互作用以产生具有抗菌作用的活性氧。在这项研究中，我们使用亚甲基蓝作为光敏剂以及红光评估了光动力疗法对感染立克次氏体的Vero细胞的作用。在用亚甲基蓝处理后48小时，接着进行30分钟的红光激发，通过定量RT-PCR确定了存活的斯洛伐克立克次氏菌的数量显着减少（降低了96％）。经预处理，斯洛伐克罗氏菌也有统计学上的显着降低（降低了99％）。据我们所知，该结果是文献中第一个证实光动力疗法对消除斯洛伐克沙门氏菌的有效性并建议该技术作为对立克次氏菌感染的良好支持疗法的第一个结果。

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