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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Early retinal and choroidal effect of photodynamic treatment in patients with polypoidal choroidal vasculopathy with or without anti-vascular endothelial growth factor: An optical coherence tomography angiography study
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Early retinal and choroidal effect of photodynamic treatment in patients with polypoidal choroidal vasculopathy with or without anti-vascular endothelial growth factor: An optical coherence tomography angiography study

机译：光动力治疗对有或没有抗血管内皮生长因子的息肉样脉络膜血管病患者的早期视网膜和脉络膜作用：光学相干断层扫描血管造影研究

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Purpose: To evaluate the early retinal and choroidal effects of the anti-vascular endothelial growth factor (antiVEGF) therapy combined with photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV).Methods: Patients diagnosed as having PCV were included in the study. In group 1, intravitreal ranibizumab and PDT was applied to six eyes. In group 2, PDT treatment only was applied to four eyes. Optical coherence tomography (OCT) angiography images and best-corrected visual acuity (BCVA) were taken from all patients before treatment and 3 days after surgery.Results: The mean age of the patients was 66.00 +/- 6.28 years. In group 1, the initial BCVA was 0.70 +/- 0.35 logMAR and the final BCVA was 1.1 +/- 0.78 logMAR. In group 2, the initial BCVA was 0.47 +/- 0.17 logMAR and the final BCVA was 0.50 +/- 0.21 logMAR. In group 1, flow rate significantly decreased in the superficial area (p = 0.028), the flow rate also decreased in other layers but they were not statistically significant (p 0.05). In group 2, the flow rate decreased but these changes were not statistically significant (p 0.05). Vascular constriction and choroidal ischemia were seen in two patients in group 1.Conclusion: In the short term, retinal and choroidal blood flow decreased after PDT treatment. However, statistically significant changes were seen only in the superficial area in group 1.
机译：目的：评价抗血管内皮生长因子（antiVEGF）疗法与光动力疗法（PDT）联合治疗息肉样脉络膜血管病（PCV）的早期视网膜和脉络膜作用。方法：将被诊断为PCV的患者纳入研究。在第1组中，将玻璃体内兰尼单抗和PDT应用于六只眼睛。在第2组中，仅对四只眼进行了PDT治疗。所有患者在治疗前和术后3天均进行了光学相干断层扫描（OCT）血管造影图像和最佳矫正视力（BCVA）。结果：患者的平均年龄为66.00 +/- 6.28岁。在第1组中，初始BCVA为0.70 +/- 0.35 logMAR，最终BCVA为1.1 +/- 0.78 logMAR。在第2组中，初始BCVA为0.47 +/- 0.17 logMAR，最终BCVA为0.50 +/- 0.21 logMAR。在第1组中，浅表区域的流速显着降低（p = 0.028），其他层的流速也有所降低，但在统计学上无统计学意义（p <0.05）。在第2组中，流速降低，但这些变化在统计学上无统计学意义（p> 0.05）。第1组中有2例患者出现血管收缩和脉络膜缺血。结论：短期内，PDT治疗后视网膜和脉络膜血流减少。但是，仅在第1组的浅表区域观察到统计学上的显着变化。

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