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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Antimicrobial photodynamic therapy with phenothiazinium photosensitizers in non-vertebrate model Galleria mellonella infected with Fusarium keratoplasticum and Fusarium moniliforme
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Antimicrobial photodynamic therapy with phenothiazinium photosensitizers in non-vertebrate model Galleria mellonella infected with Fusarium keratoplasticum and Fusarium moniliforme

机译：吩噻嗪鎓类光敏剂对非脊椎动物模型圆锥角膜霉菌和念珠菌镰刀菌感染的梅勒内尔菌的抗菌光动力学治疗

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摘要

Fusarium keratoplasticum and Fusarium moniliforme are filamentous fungi common in the environment and cause mycosis in both animals and plants. Human infections include mycetoma, keratitis and onychomycosis, while deeper mycosis occurs in immunocompromised patients. Most of the Fusarium spp. are frequently resistant to treatment with currently used antifungals. The frequent occurrence of antifungal resistance has motivated the study of antimicrobial photodynamic therapy as an alternative treatment for fungal infections. Many studies have investigated the in vitro use of antimicrobial photodynamic therapy to kill fungi, but rarely in animal models of infection. Thus, here we employed the invertebrate wax moth Galleria mellonella to study the in vivo effects of antimicrobial photodynamic therapy with three different phenothiazinium photosensitizers, methylene blue, new methylene blue N and the pentacyclic S137 against infection with microconidia of Fusarium keratoplasticum and Fusarium moniliforme. The effect of antimicrobial photodynamic therapy using these photosensitizers and light-emitting diodes with an emission peak at 635 nm and an integrated irradiance from 570 to 670 nm of 9.8 mW cm(-2) was investigated regarding the toxicity, fungal burden, larval survival and cellular immune response. The results from this model indicate that antimicrobial photodynamic therapy with methylene blue, new methylene blue N and S137 is efficient for the treatment of infection with F. keratoplasticum and F. moniliforme. The efficiency can be attributed to the fungal cell damage caused by antimicrobial photodynamic therapy which facilitates the action of the host immune response.
机译：镰状镰刀菌和单形镰刀菌是在环境中常见的丝状真菌，并且在动植物中引起霉菌病。人类感染包括粘膜瘤，角膜炎和灰指甲，而免疫功能低下的患者则发生较深的真菌病。镰刀菌属大多数。对当前使用的抗真菌药经常耐药。抗真菌药耐药性的频繁发生激发了对抗生素光动力疗法作为真菌感染替代疗法的研究。许多研究调查了体外使用抗菌光动力疗法杀死真菌的情况，但很少在感染动物模型中进行。因此，在这里我们使用无脊椎动物蜡蛾圆盘菌研究了使用三种不同的吩噻嗪鎓光敏剂，亚甲基蓝，新亚甲基蓝N和五环S137进行的抗菌光动力疗法对角斑病镰刀菌和镰刀菌微分生孢子感染的体内效应。研究了这些光敏剂和发光二极管在635 nm处的发射峰和9.8 mW cm（-2）的570至670 nm的综合辐照度的抗微生物光动力疗法的毒性，真菌负担，幼虫存活率和细胞免疫反应。该模型的结果表明，用亚甲基蓝，新的亚甲基蓝N和S137进行的抗菌光动力疗法可有效治疗角膜镰刀菌和念珠菌的感染。该效率可归因于抗微生物光动力疗法引起的真菌细胞损伤，其促进了宿主免疫应答的作用。

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