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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Effect of photodynamic therapy by 810 and 940 nm diode laser on Herpes Simplex Virus 1: An in vitro study
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Effect of photodynamic therapy by 810 and 940 nm diode laser on Herpes Simplex Virus 1: An in vitro study

机译：810和940 nm二极管激光光动力疗法对单纯疱疹病毒1的影响：体外研究

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Introduction: Herpes simplex virus (HSV) is among the most common viruses in humans. HSV1 is often responsible for oral and perioral herpetic lesions. Photodynamic therapy (PDT) is a novel antimicrobial modality that involves the use of laser and a photosensitizer with a specific wavelength. This study aimed to assess and compare the effect of PDT with 810 and 940 nm diode laser and indocyanine green (ICG) photosensitizer on HSV1.Methods: In this in vitro study, HSV1 isolated from herpes labialis and there were 6 experimental groups.The irradiation parameters were the same for all groups. Number of remaining viruses per milliliter in each group was determined using real-time polymerase chain reaction (PCR) and statistically analyzed by ANOVA.Results: The virus count in all groups significantly decreased compared to the control group (P 0.05) except in group ICG- without irradiation (P 0.05). Comparison of groups 810- and 940- (use of each laser alone) with groups 810 + and 940 + (use of each laser plus ICG) revealed that reduction in virus count in groups 810 + and 940+ was significantly greater than that in groups 810- and 940-.Conclusion: 810 nm diode laser irradiation and ICG causes the greatest reduction in number of HSV1 compared to all the other groups. ICG without laser irradiation has not significant efficacy on reduction of virus count.
机译：简介：单纯疱疹病毒（HSV）是人类最常见的病毒之一。 HSV1通常负责口腔和口腔疱疹性病变。光动力疗法（PDT）是一种新型的抗菌方法，涉及使用激光和具有特定波长的光敏剂。本研究旨在评估和比较PDT与810和940 nm二极管激光器以及吲哚菁绿（ICG）光敏剂对HSV1的影响。方法：在体外研究中，从唇疱疹分离出HSV1，有6个实验组。所有组的参数均相同。使用实时聚合酶链反应（PCR）确定每毫升中残留的病毒数量，并通过ANOVA进行统计分析。结果：除对照组外，所有组的病毒数量均显着减少（P <0.05）无辐射的ICG-（P> 0.05）。将810-和940-组（单独使用每个激光器）与810+和940+组（使用每个激光器加上ICG）进行比较，发现810+和940+组中的病毒计数降低幅度明显大于各组810-和940-。结论：与所有其他组相比，810 nm二极管激光辐照和ICG导致HSV1数量减少最多。没有激光照射的ICG在减少病毒数量方面没有显着功效。

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