Rose Bengal incorporated to α-cyclodextrin microparticles for photodynamic therapy against the cariogenic microorganism Streptococcus mutans

Alexandrino F. J. R.; Bezerra E. M.; Da Costa R. F.; Cavalcante L. R. L.; Sales F. A. M.; Francisco T. S.; Rodrigues L. K. A.; Almeida de Brito D. H.; Ricardo N. M. P. S.; Costa S. N.; de Lima-Neto P.; Barroso-Neto I. L.; Caetano E. W. S.; Freire V. N.

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Rose Bengal incorporated to α-cyclodextrin microparticles for photodynamic therapy against the cariogenic microorganism Streptococcus mutans

机译：玫瑰红结合到α-环糊精微粒中以用于对致龋微生物变形链球菌的光动力治疗

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Rose Bengal@alpha-cyclodextrin (RB@alpha-CD) microparticles (mu Ps) were prepared and the RB inclusion in alpha-CD was experimentally demonstrated through infrared, UV-VIS absorption spectroscopy and cyclic voltammetry. The RB inclusion in alpha-CD was theoretically investigated using classical molecular mechanics calculations, the simulation results showing that RB can be included in both the narrow and wide apertures of the alpha-cyclodextrin ring with configurations exhibiting average binding energies of about 27 kcal mol(-1). The prepared RB@alpha-CD microparticles were characterized through Scanning Electron Microscopy (SEM) and it was demonstrated that they are highly efficient in the photodynamic therapy against a Streptococcus mutans (the main bacteria of cariogenic dental plaque) suspension, as a concentration of RB@alpha-CD mu Ps 10 times smaller than the usual concentration of pure RB is still capable to produce significant antibacterial activity.

机译：制备了玫瑰孟加拉α-环糊精（RBα-CD）微粒（mu Ps），并通过红外，UV-VIS吸收光谱和循环伏安法实验证明了RB-α在CD中的包涵体。理论上使用经典的分子力学计算研究了RB中包含的RB，模拟结果表明RB可包含在α-环糊精环的窄孔和宽孔中，并且构型表现出平均结合能约为27 kcal mol（ -1）。通过扫描电子显微镜（SEM）对制备的RB @α-CD微粒进行了表征，结果表明它们以RB的浓度在对变形链球菌（致龋齿斑块的主要细菌）悬浮液的光动力治疗中非常有效。比普通RB浓度小10倍的α-CDmu Ps仍然能够产生显着的抗菌活性。

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来源
《Photodiagnosis and Photodynamic Therapy》 |2019年第3期|111-118|共8页
作者
Alexandrino F. J. R.; Bezerra E. M.; Da Costa R. F.; Cavalcante L. R. L.; Sales F. A. M.; Francisco T. S.; Rodrigues L. K. A.; Almeida de Brito D. H.; Ricardo N. M. P. S.; Costa S. N.; de Lima-Neto P.; Barroso-Neto I. L.; Caetano E. W. S.; Freire V. N.;
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作者单位

Univ Fed Ceara, Dept Patol & Med Legal, Programa Posgrad Microbiol Med, BR-50430275 Fortaleza, Ceara, Brazil|Fac Paulo Picanco, BR-60135218 Fortaleza, Ceara, Brazil;

Univ Fed Rural Semi Arido, Dept Ciencias Nat Matemat & Estat, BR-59625900 Mossoro, RN, Brazil;

Univ Fed Rural Semi Arido, Dept Ciencias Nat Matemat & Estat, BR-59625900 Mossoro, RN, Brazil;

Univ Fed Ceara, Dept Bioquim & Biol Mol, BR-60440970 Fortaleza, Ceara, Brazil;

Inst Fed Educ Ciencia & Tecnol Ceara, Dept Ensino, Campus Aracati, BR-62800000 Aracati, CE, Brazil;

Univ Fed Rural Semi Arido, Dept Ciencias Nat Matemat & Estat, BR-59625900 Mossoro, RN, Brazil;

Univ Fed Ceara, Fac Farm Odontol & Enfermagem, Dept Odontol Restauradora, BR-60430370 Fortaleza, Ceara, Brazil;

Univ Fed Ceara, Dept Quim Organ & Inorgan, CP 12100,Campus Pici, BR-60451970 Fortaleza, Ceara, Brazil;

Univ Fed Ceara, Dept Quim Organ & Inorgan, CP 12100,Campus Pici, BR-60451970 Fortaleza, Ceara, Brazil;

Univ Fed Ceara, Dept Engn Met & Mat, Programa Posgrad Engn & Ciencia Mat, BR-60440554 Fortaleza, Ceara, Brazil;

Univ Fed Ceara, Dept Quim Analit & Fis Quim, BR-60440900 Fortaleza, Ceara, Brazil;

Univ Fed Ceara, Dept Fis, Caixa Postal 6030,Campus Pici, BR-60440900 Fortaleza, Ceara, Brazil;

Inst Fed Educ Ciencia & Tecnol Ceara, BR-60040531 Fortaleza, Ceara, Brazil;

Univ Fed Ceara, Dept Fis, Caixa Postal 6030,Campus Pici, BR-60440900 Fortaleza, Ceara, Brazil;

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Rose Bengal; alpha-cyclodextrin microparticles; Photodynamic therapy; Antibacterial activity; Molecular interaction simulations; Antimicrobial photodynamic therapy;

机译：孟加拉玫瑰;α-环糊精微粒;光动力疗法;抗菌活性;分子相互作用模拟;抗菌光动力疗法;

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Rose Bengal incorporated to α-cyclodextrin microparticles for photodynamic therapy against the cariogenic microorganism Streptococcus mutans

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