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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles
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Photophysicochemical and photodynamic therapy properties of metallophthalocyanines linked to gold speckled silica nanoparticles

机译：金属斑点酞菁与金斑点二氧化硅纳米粒子的光物理化学和光动力疗法性质

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摘要

This work reports on the linkage of 2(3),9(10),16(17),23(24) tetrakis [(benzo[d]thiazol-2-yl phenoxy) phthalocyaninato] zinc(II) (1) and indium(III) chloride (2) to gold speckled silica (GSS) nanoparticles via gold to sulphur (Au-S) and gold to nitrogen (Au-N) self-assembly to form the conjugates: 1-GSS and 2-GSS. The formed conjugates were characterized using microscopic and spectroscopic techniques, and the photophysicochemical properties and photodynamic therapy (PDT) activity against human breast adenocarcinoma cell line (MCF-7 cells) were studied. The conjugates afforded decrease in fluorescence quantum yields with corresponding increase in triplet and singlet oxygen quantum yields when compared to phthalocyanines alone. Singlet oxygen is cytotoxic to cancer cells hence it is important for PDT. The in vitro dark toxicity of complex 2 and 2-GSS against MCF-7 cells showed = 93% viable cells within concentration ranges of 10-160 mu g/mL. 2-GSS showed enhanced PDT activity with less than 50% viable cells at 80 mu g/mL as compared to 2 and GSS alone which showed 60% viable cells within 10-160 mu g/mL. The observed improvements in the PDT activity of 2-GSS could be attributed to the high singlet oxygen generation of 2-GSS compared to 2 alone in addition to the phototoxicity of GSS.
机译：这项工作报告2（3），9（10），16（17），23（24）四[[（苯并[d]噻唑-2-基苯氧基）酞菁]锌（II）（1）和氯化铟（III）通过金与硫（Au-S）和金与氮（Au-N）的自组装形成共轭物：1-GSS和2-GSS。使用显微镜和光谱技术对形成的结合物进行表征，并研究其对人乳腺癌细胞系（MCF-7细胞）的光物理化学性质和光动力疗法（PDT）活性。当与单独的酞菁相比时，缀合物提供了荧光量子产率的降低以及三重态和单重态氧量子产率的相应增加。单线态氧对癌细胞具有细胞毒性，因此对PDT非常重要。复合物2和2-GSS对MCF-7细胞的体外暗毒性显示，在10-160μg / mL的浓度范围内，> = 93％的活细胞。 2-GSS的PDT活性增强，在80μg / mL时存活细胞少于50％，而2和GSS仅在10-160μg / mL范围内存活细胞超过60％。观察到的2-GSS的PDT活性的改善可以归因于2-GSS的高单线态氧生成（与单独的2个相比），以及GSS的光毒性。

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