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Introduction of 5-aminolevulinic acid as a theranostics agent in dentistry

机译：引入5-氨基乙酰丙酸作为牙科治疗试剂

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Objective: The aim of this paper is to study the theranostic potential of 5-Aminolevulinic Acid (5-ALA)in dentistry.Methods: Photodynamic inactivation (PDI) and fluorescence spectroscopy of Streptococcus sanguis, and laser induced fluorescence (LIF) of several decayed teeth were performed using 5-ALA.Results: In the absence of 5-ALA, 15 min illumination of the bacteria by the means of an LED light source led to only 1.16% viability reduction. On the other hand, 5-ALA revealed remarkable dark toxicity at concentrations above 20 mu M. Furthermore, the synergistic effects of 10 mu M 5-ALA and illumination by the light source for 5 and 15 min intervals led respectivelyto0.74log10 and 1.69log10 reduction of viability. Also, fluorescence spectroscopy of the bacteria showed a direct relationship between emission line intensity at 620 nm and the concentration of 5-ALA. In dental experiments, following exposing tooth with 40 mM 5-ALA, a significant auto-fluorescence growth was observed just in the decayed parts.Conclusion: Based on the strong dual modality of 5-ALA to annihilate cariogenic bacteria through photodynamic inactivation and enhancing LIF intensity for identification of dental caries, 5-ALA is proposed as a theranostic agent in dentistry.
机译：目的：研究5-氨基乙酰丙酸（5-ALA）在牙科领域的治疗潜力。方法：血链球菌的光动力学灭活（PDI）和荧光光谱，几种衰变的激光诱导荧光（LIF）。结果：在没有5-ALA的情况下，使用LED光源对细菌进行15分钟的照明仅导致活力降低了1.16％。另一方面，5-ALA在浓度超过20μM时显示出显着的暗毒性。此外，10μM 5-ALA和光源照射5分钟和15分钟的协同作用分别导致0.74log10和1.69log10降低生存能力。另外，细菌的荧光光谱显示在620nm处的发射线强度与5-ALA的浓度之间存在直接关系。在牙科实验中，用40 mM 5-ALA暴露牙齿后，仅在腐烂部位观察到了显着的自发荧光生长。结论：基于5-ALA的强双模态，通过光动力灭活和增强LIF来消除龋齿细菌为了鉴定龋齿的强度，有人提出将5-ALA作为牙科治疗剂。

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