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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Influence of antimicrobial photodynamic therapy as an adjunctive to scaling and root planing on alveolar bone loss: A systematic review and meta-analysis of animal studies
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Influence of antimicrobial photodynamic therapy as an adjunctive to scaling and root planing on alveolar bone loss: A systematic review and meta-analysis of animal studies

机译：抗菌光动力疗法作为结垢和根部平整的辅助手段对牙槽骨丢失的影响：动物研究的系统评价和荟萃分析

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Background: The study aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) as adjunctive therapy to scaling and root planing in experimental periodontitis in rats, with or without systemic involvement, by means of histometric analysis of the furcation region.Methods: Systematic search was done using PubMed/MEDLINE, SCOPUS, EMBASE and ProQuest databases. Quantitative analysis of alveolar bone loss, with subcategories for the experimental periods studied, was performed. The analysis was performed through the mean difference (MD), with 95% confidence intervals (CIs) and according to SYRCLE guidelines.Results: Nine studies were considered eligible. A statistically favorable difference was observed for the use of aPDT in all periods studied in systemically healthy animals at 7 (P 0.00001; MD: -0.71; 95% CI: [ - 0.85, - 0.58]; 12: 90%), 15 (P 0.00001; MD: -0.49; 95% CI: [ -0.62, - 0.37]; 12: 88%), and 30 (P 0.00001; MD: -0.53; 95% CI: [ - 0.65, - 0.41]; 12: 80%) days postoperatively. The difference was also observed for modified animals at 7 (P 0.00001; MD: -1.03; 95% CI: [ -1.43, - 0.62]; 12: 97%), 15 (P 0.00001; MD: -1.04; 95% CI: [ - 1.62, - 0.46]; 12: 99%), and 30 (P 0.00001; MD: -0.88; 95% CI: [ -1.37, -0.39]; 12: 97%) days postoperatively.Conclusion: The adjunctive use of aPDT favored the reduction of alveolar bone loss in experimental periodontitis in rats, and this result was more evident in systemically compromised rats.
机译：背景：这项研究旨在通过对分叉区进行组织分析，评估抗菌光动力疗法（aPDT）作为辅助疗法对实验性牙周炎大鼠牙周组织结垢和牙根滑行的效果。使用PubMed / MEDLINE，SCOPUS，EMBASE和ProQuest数据库完成。进行了牙槽骨丢失的定量分析，并研究了实验阶段的子类别。根据SYRCLE指南，通过均值差（MD），95％置信区间（CI）进行分析。结果：9项研究被认为是合格的。在系统健康动物中研究的所有时期中，使用aPDT的统计差异均达到7（P <0.00001； MD：-0.71； 95％CI：[-0.85，-0.58]； 12：90％），15 （P <0.00001; MD：-0.49; 95％CI：[-0.62，-0.37]; 12：88％）和30（P <0.00001; MD：-0.53; 95％CI：[-0.65，-0.41 ]； 12：80％）天。在7（P <0.00001; MD：-1.03; 95％CI：[-1.43，-0.62]; 12：97％），15（P <0.00001; MD：-1.04; 95 ％CI：[-1.62，-0.46]； 12：99％）和30（P <0.00001； MD：-0.88； 95％CI：[-1.37，-0.39]； 12：97％）。 ：aPDT的辅助使用有助于减少大鼠实验性牙周炎的牙槽骨损失，这一结果在系统性受损的大鼠中更为明显。

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